Target List
JAK / STAT Signaling
Janus Kinases
JAK1, JAK2, JAK3, TYK2
STAT Family Members
STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B
JAK / STAT Signaling Regulators
CISH, PIAS1, PIAS2, PIAS3, PRL, PTPN1 (PTP1B), PTPRC, SH2B2, SIRPA, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Cell Surface Receptors
EGFR (ERBB1), EPOR, F2R (PAR1), GHR, IFNAR1, IFNGR1, IL10RA, IL10RB, IL2RG, IL4R (CD124), IL6ST (GP130), INSR, LOC100524633, MPL, SH2B1
SH3 / SH2 Adaptor Proteins
GRB2, SRC, STAM
STAT-Interacting Transcription Factors & Regulators
Transcriptional Regulation
SMAD3 (MADH3), SPI1
Transcription Factors
JUNB, SP1, USF1
Transcriptional Coactivators & Corepressors
JUNB, PIAS1, SMAD1 (MADH1), SP1
Other Transcription Factors & Regulators
CEBPB, GATA3, IRF1, IRF9 (ISGF3G), JUN, MYC, NFKB1, NR3C1 (GRL), SMAD2 (MADH2), SMAD4 (MADH4)
STAT-Induced
STAT1-Induced
CXCL9 (MIG), IRF1, JUNB, NOS2
STAT3-Induced
A2M, BCL2L1 (BCL-X, BCLXL), CDKN1A (p21CIP1, WAF1), CEBPD, CRP, FAS (TNFRSF6), IRF1, LRG1, MCL1, MYC, SOCS1, SOCS3
STAT4-Induced
FCGR1A, IFNG, IRF1, MYC
STAT5-Induced
BCL2L1 (BCL-X, BCLXL), CDKN1A (p21CIP1, WAF1), IRF1, OSM
STAT6-Induced
FCER2, GATA3, IL4, IL4R (CD124)
STAT1 / STAT2 / p48 Induced
ISG15 (G1P2), OAS1
Apoptosis
AKT1, BCL2L1 (BCL-X, BCLXL), CDKN1A (p21CIP1, WAF1), F2R (PAR1), FAS (TNFRSF6), MCL1, NFKB1, PRLR, STAT1
Cell Growth and / or Maintenance
Cell Cycle
CDKN1A (p21CIP1, WAF1), EGFR (ERBB1), F2R (PAR1), IRF1, JAK2, MYC, STAT1
Cell Growth
A2M, CISH, EGFR (ERBB1), GHR, IFNG, IL4, INSR, OSM, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Cell Proliferation
IL2RG, IL4, LOC100524633, MPL, OSM, SMAD3 (MADH3)
Cell Differentiation
EPO, IL20, IL4, NOS2, SOCS2, SOCS5, SPRY1
Immune Response
Acute-Phase Response
CEBPB, CRP, STAT3
Humoral Immune Response
FCER2, IL4, NFKB1
Inflammatory Response
CEBPB, CRP, CXCL9 (MIG), IL20, NFKB1, NOS2, NR3C1 (GRL)
Other Immune Response Genes
CXCL9 (MIG), FAS (TNFRSF6), FCGR1A, GBP1, GBP2, ISG15 (G1P2), IFNG, IL2RG, IL4R (CD124), IL6ST (GP130), IRF1, IRF9 (ISGF3G), OAS1, OSM, PRLR, PTPN11, STUB1