Rnf220 Gene Summary [Rat]
Predicted to enable beta-catenin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein autoubiquitination; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to act upstream of or within nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm; nuclear lamina; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf220 |
| Official Name | ring finger protein 220 [Source:RGD Symbol;Acc:1598210] |
| Ensembl ID | ENSRNOG00000019236 |
| Bio databases IDs | |
| Aliases | ring finger protein 220 |
| Synonyms | 4732477A13, 4931406I20Rik, 5730503K05Rik, C1orf164, FLJ10597, HLD23, ring finger protein 220 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnf220 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E3 ubiquitin-protein ligase RNF220
- beta-catenin binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- zDHHC ankyrin repeat binding domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Crohn disease
- leukodystrophy type 23 with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy
- rotator cuff injury
- systemic autoimmune syndrome
role in cell
- expression in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- nucleoplasm
- nuclear lamina
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnf220 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dorsal/ventral neural tube patterning
- noradrenergic neuron development
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of transcription regulatory region DNA binding
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein monoubiquitination
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- nuclear lamina
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- beta-catenin binding