Selenon Gene Summary [Rat]
This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Knockout mice deleted for this gene exhibit abnormal lung development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. [provided by RefSeq, Feb 2024]
Details
| Type | Protein Coding |
| Official Symbol | Selenon |
| Official Name | selenoprotein N [Source:RGD Symbol;Acc:1304574] |
| Ensembl ID | ENSRNOG00000017078 |
| Bio databases IDs | |
| Aliases | selenoprotein N |
| Synonyms | 1110019I12RIK, AI414492, CFTD, CMYO3, CMYP3, LOC689675, MDRS1, RSMD1, RSS, selenoprotein N, SELN, SEPN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Selenon often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rigid spine syndrome
- SELENON mutation positive congenital myopathy
- SEPN1-related disorder
- preeclampsia
- weight gain
- muscular dystrophy
- congenital myopathy with fiber type disproportion
- cap myopathy 1
- centronuclear myopathy
- kyphosis
regulates
- Ca2+
- adenosine triphosphate
- RYR
- ascorbic acid
role in cell
- release in
- apoptosis
- differentiation
- number
- diameter
- response by
- organization
- biogenesis
- size
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Extracellular Space
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Selenon gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity involved in regulation of muscle adaptation
- calcium ion homeostasis
- regulation of ryanodine-sensitive calcium-release channel activity
- mitochondrion organization
- respiratory system process
- lung alveolus development
- skeletal muscle fiber development
- satellite cell differentiation
- multicellular organismal response to stress
- positive regulation of skeletal muscle cell proliferation
- cellular response to oxidative stress
- satellite cell maintenance involved in skeletal muscle regeneration
- cellular response to caffeine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- calcium ion binding