Mllt3 Gene Summary [Rat]
Predicted to enable chromatin binding activity; lysine-acetylated histone binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including hematopoietic stem cell differentiation; positive regulation of DNA-templated transcription; and regulation of stem cell division. Predicted to act upstream of or within gene expression; regionalization; and regulation of Wnt signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mllt3 |
| Official Name | MLLT3, super elongation complex subunit [Source:RGD Symbol;Acc:620940] |
| Ensembl ID | ENSRNOG00000011280 |
| Bio databases IDs | |
| Aliases | MLLT3, super elongation complex subunit |
| Synonyms | 2210011H10Rik, 2610012I03RIK, 3830408D16Rik, AF9, D4Ertd321e, MLLT3 super elongation complex subunit, MLLT3, super elongation complex subunit, myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, YEATS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mllt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YEATS domain family, chromatin reader proteins
- histone binding
- transcription regulator
- ANC1 homology domain (AHD)
- protein binding activity, bridging
- chromatin binding
- protein binding
- YEATS family
- prokaryotic YEATS domain
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- COVID-19
- open-angle glaucoma
- gout
- leukemia
- organismal death
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- azoxymethane/dextran sodium sulfate induced colorectal cancer
role in cell
- expression in
- apoptosis
- proliferation
- growth
- migration
- cell death
- differentiation
- organization
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mllt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- anterior/posterior pattern specification
- hemopoietic stem cell differentiation
- regulation of stem cell division
- gene expression
- segment specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- transcription elongation factor complex
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- histone binding
- histone acetyl-lysine binding
- chromatin binding
- binding, bridging