Hhip Gene Summary [Rat]
Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cell surface and plasma membrane. Biomarker of diabetic neuropathy and primary biliary cholangitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hhip |
| Official Name | Hedgehog-interacting protein [Source:RGD Symbol;Acc:1564108] |
| Ensembl ID | ENSRNOG00000018268 |
| Bio databases IDs | |
| Aliases | Hedgehog-interacting protein |
| Synonyms | Hedgehog-interacting protein, HHIP1, HIP, Hip1, LOC100366089, RGD1564108 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hhip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- Folate receptor family
- EGF_CA
Pathways
Biological processes and signaling networks where the Hhip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- epithelial neoplasia
- liver cancer
- cancer
- epithelial cancer
- hepatocellular carcinoma
- skin neoplasia
- chordoma
- bone cancer
- colorectal cancer
role in cell
- proliferation
- apoptosis
- co-expression in
- chemorepulsion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hhip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- neuroblast proliferation
- regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of signal transduction
- signal transduction
- negative regulation of apoptotic process
- negative regulation of smoothened signaling pathway
- skeletal system morphogenesis
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- hedgehog family protein binding