Ptprq Gene Summary [Rat]
Predicted to enable phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprq |
| Official Name | protein tyrosine phosphatase, receptor type, Q [Source:RGD Symbol;Acc:620779] |
| Ensembl ID | ENSRNOG00000056915 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, Q |
| Synonyms | DFNA73, DFNB84, DFNB84A, LOC100129165, LOC105378254, protein tyrosine phosphatase receptor type Q, protein tyrosine phosphatase, receptor type, Q, PTPGMC1, PTP-I32039, rPTP-GMC1, R-PTP-Q |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptprq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- TM proximal of protein tyrosine phosphatase, receptor type J
- Protein-tyrosine phosphatase
- Uroplakin IIIb, IIIa and II
- catalytic domain
- FN3
- Protein tyrosine phosphatase, catalytic domain
- Purple acid Phosphatase, N-terminal domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Ptprq gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness
- autosomal recessive deafness type 84
- autosomal recessive nonsyndromic postlingual hearing loss
- autosomal dominant deafness type 73
- hereditary age-related sensorineural hearing loss
- sporadic age-related sensorineural hearing loss
- absent pinna reflex
- non-insulin-dependent diabetes mellitus
- hearing loss
- ear malformation
regulates
- phosphatidylinositol-3,4,5-triphosphate
- phosphtidylinositol 5-phosphate
- phosphatidylinositol 3,4-bisphosphate
- phosphatidylinositol 3,5-bisphosphate
- phosphatidylinositol 4-phosphate
- phosphatidylinositol-3-phosphate
- phosphatidylinositol 4,5-bisphosphate
role in cell
- number
- differentiation
- apoptosis
- proliferation
- elongation
- elongation in
- length
- abnormal morphology
- degeneration
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- stereocilia
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptprq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- receptor complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein tyrosine phosphatase activity