Actn1 Gene Summary [Rat]
Enables cytoskeletal regulatory protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; focal adhesion assembly; and platelet formation. Located in actin cytoskeleton; dendritic spine; and plasma membrane. Is active in postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actn1 |
| Official Name | actinin, alpha 1 [Source:RGD Symbol;Acc:70907] |
| Ensembl ID | ENSRNOG00000056756 |
| Bio databases IDs | |
| Aliases | actinin, alpha 1 |
| Synonyms | 3110023F10Rik, Actinin alpha 1, actinin, alpha 1, Actinin α 1, actinin, α 1, Actn1a, Alpha-Actinin, Alpha-Actinin1, Alpha-ACTN1, BDPLT15, α-Actinin, α-Actinin1, α-ACTN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- transcription regulator
- transcription co-activator
- vinculin binding
- Ca2+ insensitive EF hand
- head domain
- EFh_PI-PLC
- EF-hand domain
- EF hand
- double-stranded RNA binding
- ion channel binding
- rod domain
- SPEC
- EF-hand, calcium binding motif
- Calponin homology domain
- actinin binding
- EF-hand domain pair
- EFh
- protein domain specific binding
- protein binding
- cytoskeletal regulatory protein binding
- actin filament binding
- Spectrin repeats
- actin-binding domain
- integrin binding
- protein homodimerization
- Spectrin repeat
- calponin homology (CH) domain superfamily
- structural molecule
Pathways
Biological processes and signaling networks where the Actn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Paxillin Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Remodeling of Epithelial Adherens Junctions
- Sertoli Cell-Sertoli Cell Junction Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma formation
- platelet-type bleeding disorder type 15
- astrocytoma
- migraines
- organismal death
- severe acute respiratory syndrome
- hereditary disorder
- post-traumatic stress disorder
- Huntington disease
- periodontitis
role in cell
- growth
- formation
- organization
- size
- migration
- assembly
- trafficking
- macropinocytosis by
- tubulation
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- cortical cytoskeleton
- ruffle
- cortical actin cytoskeleton
- cytoskeleton
- Cytoplasm
- cilia
- cell borders
- Extracellular Space
- punctate structures
- focal adhesions
- actin cytoskeleton
- Plasma Membrane
- Mitochondria
- actin filaments
- intercellular junctions
- desmosomes
- cell-cell contacts
- sarcomere
- secretory granule membrane
- cytosol
- terminal web
- lateral plasma membrane
- perinuclear space
- alpha granules
- dendritic spines
- synapse
- sarcolemma
- Z line
- actin stress fibers
- anchoring junction
- tight junctions
- zonula adherens
- membrane rafts
- brush border
- cellular protrusions
- pseudopodia
- cell membrane leading edge
- dendrites
- dendritic shafts
- exosomes
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- muscle cell development
- platelet formation
- actin filament network formation
- actin filament organization
- regulation of apoptotic process
- focal adhesion assembly
- actin cytoskeleton organization
- platelet activation
- platelet aggregation
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular region
- actin filament
- cell projection
- plasma membrane
- Z disc
- extracellular space
- cell-cell junction
- extracellular vesicular exosome
- brush border
- focal adhesion
- cytoplasm
- fascia adherens
- stress fiber
- ruffle
- cell junction
- cytosol
- pseudopodium
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein homodimerization activity
- protein binding
- double-stranded RNA binding
- calcium ion binding
- ligand-dependent nuclear receptor transcription coactivator activity
- vinculin binding
- integrin binding
- ion channel binding