Snx27 Gene Summary [Rat]
Enables calcium-dependent protein binding activity; ionotropic glutamate receptor binding activity; and phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including negative regulation of inward rectifier potassium channel activity; positive regulation of AMPA glutamate receptor clustering; and vesicle-mediated transport to the plasma membrane. Located in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx27 |
| Official Name | sorting nexin 27 [Source:RGD Symbol;Acc:628705] |
| Ensembl ID | ENSRNOG00000020893 |
| Bio databases IDs | |
| Aliases | sorting nexin 27 |
| Synonyms | 5730552M22Rik, C79375, D13Mgi25, ESTM45, ESTM47, MRT1, MY014, R75405, SNTX27, sorting nexin 27, sorting nexin family member 27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snx27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- RA domain
- phosphoinositide binding domain
- canonical PDZ domain
- Sorting Nexin 17 FERM C-terminal domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- ionotropic glutamate receptor binding
- FERM subdomain f1
- phosphatidylinositol binding
- FERM subdomain f3
- FERM subdomain f2
- FERM domain
- Ubl1_cv_Nsp3_N-like
- The Phox Homology domain, a phosphoinositide binding module
- PDZ binding motif
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- severe myoclonic epilepsy in infancy
- atopic dermatitis
- breast cancer
- schizophrenia
- growth failure
- hydrocephalus
- severe combined immunodeficiency
- invasive breast cancer
role in cell
- phosphorylation in
- expression in
- proliferation
- production in
- quantity
- remodeling
- loss
- organization
- density
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- postsynaptic region
- endosomes
- vesicles
- immunological synapses
- cytosol
- synapse
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snx27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- signal transduction
- endosomal transport
- endosome to lysosome transport
- intracellular protein transport
- establishment of natural killer cell polarity
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- endosome
- intracellular membrane-bounded organelle
- retromer complex
- cytosol
- WASH complex
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- phosphatidylinositol-3-phosphate binding