Ctnnb1 Gene Summary [Rat]
Enables several functions, including alpha-catenin binding activity; delta-catenin binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and lateral plasma membrane. Part of protein-containing complex. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease; colorectal cancer; heroin dependence; and traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctnnb1 |
| Official Name | catenin beta 1 [Source:RGD Symbol;Acc:70487] |
| Ensembl ID | ENSRNOG00000054172 |
| Bio databases IDs | |
| Aliases | catenin beta 1 |
| Synonyms | armadillo, Beta-cat, beta CATENIN, Bfc, CATENIN beta, catenin beta 1, CATENIN β, catenin β 1, CATNB, CTNB1, CTNNB, CTNN beta, CTNN β, EVR7, Mesc, MRD19, NEDSDV, β-cat, β-catenin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctnnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- ubiquitin-targeting sequence
- transcription regulator
- Armadillo/beta-catenin-like repeat
- alpha-catenin binding
- transcription co-activator
- transcription activation domain
- transcription factor binding
- APC binding domain
- chromatin binding
- estrogen receptor binding
- destruction box
- alpha catenin-binding domain
- cytoplasmic domain
- ubiquitin binding domain
- intracellular domain
- ion channel binding
- cadherin binding
- CTNNAbd_CTNNB1-like
- armadillo repeat domain
- phosphatase binding
- ubiquitin protein ligase binding
- Gsk3 phosphorylation site
- core domain, structural
- activation domain
- ligand-dependent nuclear receptor interactor
- protein kinase binding
- nucleic acid binding
- GSK3 beta phosphorylation site
- protein phosphatase binding
- nuclear localization sequence
- enzyme binding
- central domain
- protein domain specific binding
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
- Rxl motif
- phosphorylation site
- arginine rich motif
- binding protein
- kinase binding
- Armadillo/beta-catenin-like repeats
- CAD domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Ctnnb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endometrial Cancer Signaling
- Ephrin B Signaling
- Epithelial Adherens Junction Signaling
- Erythropoietin Signaling
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Gα12/13 Signaling
- Human Embryonic Stem Cell Pluripotency
- ILK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- p53 Signaling
- Polyamine Regulation in Colon Cancer
- Remodeling of Epithelial Adherens Junctions
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cytopathic effect
- hepatic fibrosis
- liver adenoma
- adenoma formation
- liver neoplasia
- epithelial neoplasia
- benign neoplasia
- neoplasia
- epithelial cancer
- cancer
role in cell
- survival
- differentiation
- phosphorylation in
- migration
- activation in
- adhesion
- production in
- expression in
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- insoluble fractions
- apicolateral membrane
- glutaminergic synapse
- inner surface
- cell junction
- intracellular membrane-bounded organelle
- intracellular compartment
- exocytic vesicle
- organelle
- Cytoplasm
- invadopodia
- cilia
- cell surface
- cell borders
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- postsynaptic region
- membrane surface
- cellular membrane
- inner membrane
- focal adhesions
- filamentous network
- cell cortex
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- intercellular junctions
- endothelial paracellular clefts
- cell-cell contacts
- cytosol
- basal cell surfaces
- lateral cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- cytoplasmic face of plasma membrane
- membrane ruffles
- caveolar membranes
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear rim
- nuclear envelope
- pronucleus
- dendritic spines
- growth cone
- paranodes
- synaptosomes
- synapse
- intercalated disks
- Z line
- apical cortex
- cytoplasmic vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- fibrils
- anchoring junction
- gap junctions
- tight junctions
- junctional complexes
- lateral cell-cell contacts
- microsomal membrane
- membrane rafts
- cellular protrusions
- microvilli
- filopodia
- cell membrane leading edge
- chromatin
- postsynaptic spines
- perikaryon
- axons
- dendrites
- dendritic shafts
- cell-cell adherens junctions
- lamellipodia
- macropinosomes
- detergent-soluble fraction
- cytoskeletal fraction
- synaptosomal fractions
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctnnb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- negative regulation of angiogenesis
- lung epithelial cell differentiation
- epithelial cell proliferation involved in prostate gland development
- synaptic vesicle clustering
- regulation of angiogenesis
- positive regulation of epithelial cell proliferation involved in prostate gland development
- dorsal/ventral axis specification
- central nervous system vasculogenesis
- embryonic axis specification
- lens morphogenesis in camera-type eye
- proximal/distal pattern formation
- regulation of anagen
- positive regulation of transcription elongation from RNA polymerase II promoter
- anterior/posterior axis specification
- neuroblast proliferation
- synaptic vesicle transport
- negative regulation of transcription, DNA-dependent
- positive regulation of skeletal muscle tissue development
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- gastrulation with mouth forming second
- cell fate specification
- hair cell differentiation
- regulation of centromeric sister chromatid cohesion
- positive regulation of branching involved in lung morphogenesis
- synaptic transmission
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- regulation of nephron tubule epithelial cell differentiation
- renal outer medulla development
- renal inner medulla development
- regulation of protein localization at cell surface
- metanephros morphogenesis
- endodermal cell fate commitment
- male genitalia development
- mesenchymal cell proliferation involved in lung development
- positive regulation of stem cell proliferation
- cellular response to growth factor stimulus
- epithelial to mesenchymal transition
- hair follicle morphogenesis
- adherens junction assembly
- layer formation in cerebral cortex
- regulation of calcium ion import
- negative regulation of cell proliferation
- fungiform papilla formation
- positive regulation of cell proliferation
- hair follicle placode formation
- chondrocyte differentiation
- outflow tract morphogenesis
- apoptotic signaling pathway
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of neuron apoptotic process
- thymus development
- canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
- MAPK cascade
- regulation of smooth muscle cell proliferation
- neuron migration
- smooth muscle cell differentiation
- neuron fate determination
- regulation of fibroblast proliferation
- stem cell proliferation
- negative regulation of osteoclast differentiation
- osteoblast differentiation
- negative regulation of protein sumoylation
- positive regulation of determination of dorsal identity
- oligodendrocyte differentiation
- lung induction
- T cell differentiation in thymus
- protein polyubiquitination
- positive regulation of MAPK cascade
- glial cell fate determination
- regulation of centriole-centriole cohesion
- nephron tubule formation
- branching involved in ureteric bud morphogenesis
- trachea formation
- protein localization at cell surface
- epithelial tube branching involved in lung morphogenesis
- fibroblast growth factor receptor signaling pathway
- transcription from RNA polymerase II promoter
- positive regulation of endothelial cell differentiation
- negative regulation of oligodendrocyte differentiation
- embryonic digit morphogenesis
- hindbrain development
- bone resorption
- regulation of protein ubiquitination
- embryonic forelimb morphogenesis
- detection of muscle stretch
- regulation of synapse assembly
- embryonic hindlimb morphogenesis
- acinar cell differentiation
- genitalia morphogenesis
- stem cell maintenance
- synapse organization
- positive regulation of neuroblast proliferation
- positive regulation of mesenchymal cell proliferation
- positive regulation of heparan sulfate proteoglycan biosynthetic process
- regulation of secondary heart field cardioblast proliferation
- negative regulation of mitotic cell cycle, embryonic
- negative regulation of gene expression
- cellular response to indole-3-methanol
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of gene expression
- mesenchymal stem cell differentiation
- myoblast proliferation
- response to estradiol stimulus
- positive regulation of myoblast proliferation
- regulation of neurogenesis
- oviduct development
- endothelial tube morphogenesis
- positive regulation of fibroblast growth factor receptor signaling pathway
- cell adhesion
- odontogenesis of dentin-containing tooth
- hypothalamus development
- ectoderm development
- embryonic foregut morphogenesis
- epithelial cell differentiation involved in prostate gland development
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- neural plate development
- patterning of blood vessels
- canonical Wnt receptor signaling pathway
- pancreas development
- embryonic skeletal limb joint morphogenesis
- regulation of T cell proliferation
- cell-matrix adhesion
- establishment of blood-brain barrier
- positive regulation of cell differentiation
- cell maturation
- embryonic heart tube development
- renal vesicle formation
- osteoclast differentiation
- negative regulation of canonical Wnt receptor signaling pathway
- oocyte development
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of telomere maintenance via telomerase
- regulation of myelination
- negative regulation of chondrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- apicolateral plasma membrane
- lateral plasma membrane
- Scrib-APC-beta-catenin complex
- synapse
- nucleoplasm
- transcription factor complex
- tight junction
- extracellular vesicular exosome
- focal adhesion
- apical part of cell
- postsynaptic membrane
- cytosol
- beta-catenin-TCF7L2 complex
- lamellipodium
- spindle pole
- plasma membrane
- beta-catenin destruction complex
- nucleus
- microvillus membrane
- Z disc
- euchromatin
- centrosome
- adherens junction
- perinuclear region of cytoplasm
- cell-cell junction
- cytoplasm
- fascia adherens
- cell cortex
- membrane
- protein-DNA complex
- cell junction
- macromolecular complex
- catenin complex
- basolateral plasma membrane
- cell periphery
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ligand-dependent nuclear receptor binding
- protein phosphatase binding
- chromatin binding
- ion channel binding
- receptor binding
- transcription corepressor binding
- alpha-catenin binding
- transcription cofactor binding
- protein binding
- ubiquitin protein ligase binding
- SMAD binding
- transcription coactivator activity
- cadherin binding
- I-SMAD binding
- estrogen receptor binding
- kinase binding
- enzyme binding