BCAR4 Gene Summary [Human]
This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | BCAR4 |
| Official Name | breast cancer anti-estrogen resistance 4 [Source:HGNC Symbol;Acc:HGNC:22170] |
| Ensembl ID | ENSG00000262117 |
| Bio databases IDs | |
| Aliases | breast cancer anti-estrogen resistance 4 |
| Synonyms | breast cancer anti-estrogen resistance 4 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- miR-665 (and other miRNAs w/seed CCAGGAG)
- YAP1
disease
- cancer
- neoplasia
- metastasis
- organismal death
- major depression
- non-small cell lung cancer
- cervical cancer
- testicular germ cell tumor
- germ cell neoplasia
- chondrosarcoma
regulated by
- YAP1
- quercetin
role in cell
- phosphorylation in
- migration
- proliferation
- expression in
- cell cycle progression
- invasion by
- apoptosis
- glycolysis in
- acetylation in
- trastuzumab sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown