YAP1 Gene Summary [Human]
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | YAP1 |
| Official Name | Yes1 associated transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:16262] |
| Ensembl ID | ENSG00000137693 |
| Bio databases IDs | |
| Aliases | Yes1 associated transcriptional regulator |
| Synonyms | COB1, YAP, Yap2, YAP65, Yes1 associated transcriptional regulator, yes-associated protein 1, YKI, Yorkie |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- transcription regulator
- transcription co-activator
- Akt phosphorylation site
- nucleic acid binding
- transcription co-repressor
- WW class I binding domain
- transcription cofactor
- transcription factor binding
- chromatin binding
- protein binding
- glutamine-rich domain
- sequence-specific DNA binding
- proline tyrosine motif
- WW domain
- Domain with 2 conserved Trp (W) residues
- double-stranded DNA binding
- ligand-binding domain
- WW class II binding domain
- WW
Pathways
Biological processes and signaling networks where the YAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- metastasis
- cancer
- colorectal cancer
- pancreatic ductal adenocarcinoma
- gastric cancer
- Huntington disease
- macular degeneration
- abdominal aortic aneurysm
role in cell
- phosphorylation in
- expression in
- activation
- quantity
- number
- differentiation
- migration
- invasion by
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Mitochondria
- intercellular junctions
- cytosol
- apical membrane
- nucleoplasm
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- lung epithelial cell differentiation
- response to progesterone stimulus
- bud elongation involved in lung branching
- heart process
- wound healing
- positive regulation of cell growth
- epithelial cell proliferation
- notochord development
- lateral mesoderm development
- positive regulation of transcription, DNA-dependent
- trophectodermal cell differentiation
- positive regulation of epithelial cell proliferation
- regulation of metanephric nephron tubule epithelial cell differentiation
- positive regulation of protein localization to nucleus
- macromolecular complex assembly
- cell morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- embryonic heart tube morphogenesis
- response to DNA damage stimulus
- negative regulation of gene expression
- keratinocyte differentiation
- cellular response to gamma radiation
- negative regulation of epithelial cell differentiation
- polarized epithelial cell differentiation
- positive regulation of gene expression
- regulation of neurogenesis
- organ growth
- regulation of stem cell proliferation
- extrinsic apoptotic signaling pathway
- paraxial mesoderm development
- vasculogenesis
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- glandular epithelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- regulation of keratinocyte proliferation
- negative regulation of stem cell differentiation
- somatic stem cell maintenance
- canonical Wnt receptor signaling pathway
- interleukin-6-mediated signaling pathway
- cardiac muscle tissue regeneration
- negative regulation of fat cell differentiation
- intestinal epithelial cell development
- tissue homeostasis
- cellular response to retinoic acid
- negative regulation of extrinsic apoptotic signaling pathway
- hippo signaling cascade
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- cell-cell junction
- cytoplasm
- membrane
- cell junction
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- transcription corepressor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding