GeneGlobe ID: JHS-005Z | Cat. No.: | QIAseq RNA Fusion XP Panels

QIAseq RNA Fusion XP Sarcoma Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

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Product Specification

Target List

Alveolar Soft Part Sarcomas
ASPSCR1, TFE3, APC, KMT2D, PTEN
Angiosarcomas & Epitheliod Haemangioendotheliomas
CAMTA1, CEP85L, CIC, LEUTX, ROS1, TFE3, YAP1, AKT1, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BRAF, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, HRAS, JAK3, KMT2D, KRAS, MED12, MET, MLH1, MPL, NCOR1, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, PTEN, TERT, TRAF7, TRRAP, ZFHX3
Askins Tumors
ERG, EWSR1, FLI1, FUS
Chondrosarcomas
ACVR2A, CDX1, EWSR1, FN1, HEY1, IRF2BP2, NCOA2, NR4A3 (NOR1), TAF15, TCF12, TFG, ALK, AR, ARID1A, CDKN2A (P16INK4A), DNMT3A, ERBB3, H3-3A, HRAS, IDH1, IDH2, IRS4, JAK1, KMT2D, MLLT3, NRAS, POLE, PTEN, SMAD2 (MADH2), SMARCB1, TERT, ZFHX3
Clear Cell Sarcomas
ATF1, CREB1, EWSR1, FLI1, NUTM2B, YWHAE, BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), NRAS, PTEN
Congenital (Infantile) Fibrosarcomas
ETV6, MET, NTRK3, TFG
Dermatofibrosarcoma Protuberans
COL1A1, PDGFB, FGFR1, MED12
Dermatofibrosarcomas Protuberans
COL1A1, PDGFB
Desmoplastic Small Round Cell Tumors
ERG, EWSR1, FLI1, PATZ1, WT1, APC, CIC, CREBBP (CBP), DAXX, EGFR (ERBB1)
Endometrial Stromal Sarcomas
ALK, BCOR, CXorf67, EPC1, FN1, JAZF1, MBTD1, MEAF6, NUTM2A, NUTM2B, PHF1, SUZ12, YWHAE, ZC3H7B, ASXL1, CTNNB1, ERBB3, FBXW7, FGFR2, FLT3, KRAS, MED12, PIK3CA (p110-alpha)
Epithelioid Sarcomas
CREB3L1, CREB3L2, EWSR1, FUS, KLF17, SS18, SSX1, DICER1, SMARCB1
Ewing's Sarcomas
CIC, ERG, ETV1, ETV4, EWSR1, FEV, FLI1, FOXO4, FUS, NFATC2, SMARCA5, SP3, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BCOR, BRAF, CBL, CD209, CD79B, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, DAXX, DGCR8, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), EZH2, FBXW7, FGFR1, FGFR3, FGFR4, GNAS, HRAS, IDH1, IDH2, IRS4, KIT (CD117), KMT2D, KRAS, MED12, MET, MLH1, MLLT3, MYOD1, NCOR1, NCOR2, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, POLE, PTEN, RECQL4, SMARCB1, TERT, TNC, TRAF7, TRRAP, ZFHX3
Fibrosarcomas
BRAF, COL1A1, CREB3L1, CREB3L2, EWSR1, FUS, LMNA, NTRK1, PDGFB, TOM1L2, BCOR, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), EZH2, FGFR3, FLT3, KIT (CD117), KRAS, NRAS, POLE, PTEN, TERT, TRAF7
Leiomyosarcomas
EWSR1, HMGA2, PBX3, WT1, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, CBL, CREBBP (CBP), DAXX, DNMT3A, ERBB3, EZH2, FGFR1, FGFR3, JAK1, JAK3, MET, MPL, NCOR1, PAX5, RECQL4, TRAF7
Liposarcomas
DDIT3 (GADD153, CHOP), EWSR1, FUS, HMGA2, LGR5, NUP107, AKT1, ALK, APC, ARID1A, ATM, BRAF, CBL, CD79B, CDKN2A (P16INK4A), CIC, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), FBXW7, FGFR1, FGFR2, FGFR3, HRAS, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MLH1, MPL, NCOR1, NOTCH2, PBRM1, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), POLE, PTEN, RECQL4, TERT, ZFHX3
Myofibroblastic Sarcomas
ALK, LMNA, NTRK1, RELA, ROS1, SRF, TFG, TPM3, YWHAE
Myxofibrosarcomas
CREB3L1, CREB3L2, FUS
Myxoid Chondrosarcomas
NR4A3 (NOR1), TAF15
Perivascular Epithelioid Cell Tumors (PEComa)
DVL2, SFPQ, TFE3, ALK, ATM, CIC, JAK3, MED12, NOTCH2
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)
CITED2, MED12, PRDM10, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BRAF, CD79B, CDKN2A (P16INK4A), CIC, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR4, FLT3, HRAS, IDH1, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MET, MLH1, MYOD1, NCOR1, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), POLE, PTEN, PTPN11, SMARCB1, TERT, TRAF7, ZFHX3
Rhabdoid Tumors
NCOA4, RET, CREBBP (CBP), PBRM1, SMARCB1
Rhabdomyosarcomas
CITED2, EWSR1, FLI1, FOXO1, NCOA1, NCOA2, PAX3, PAX7, SRF, TEAD1, VGLL2, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BCOR, BRAF, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, DAXX, DGCR8, DICER1, DNMT3A, ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GNAS, HRAS, IRS4, KIT (CD117), KMT2D, KRAS, MED12, MET, MLH1, MPL, MYOD1, NCOR2, NOTCH2, NRAS, PDGFRA, PIK3CA (p110-alpha), POLE, PTEN, PTPN11, RECQL4, SH2B3, SMARCB1, TNC, TRAF7, TRRAP, WNK2, ZFHX3
Small Round Cell Tumors
ERG, ETV1, EWSR1, FEV, FLI1, FOXO1, PAX3
Solitary Fibrous Tumors
NAB2, STAT6, ALK, APC, ARID2, CBL, FBXW7, FGFR1, FGFR3, KMT2D, PIK3R1 (p85-ALPHA), PTEN, TERT
Synovial Sarcomas
COL6A3, CSF1 (MCSF), S100A10, SS18, SS18L1, SSX1, SSX2, SSX4B, ARID2, BCOR, BRAF, CTNNB1, EGFR (ERBB1), FGFR1, HRAS, KMT2D, KRAS, MED12, MLH1, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, TERT, TRAF7, TRRAP, ZFHX3
Undifferentiated; Unclassified or Other Sarcomas
ATF1, BCOR, CCNB3, CREM, ERG, ETV4, EWSR1, FGF1, FGFR1, FLI1, FN1, FOXO1, FUS, GLI1, JAZF1, MAML3, MKL2, NPM1, PAX3, PLAG1, POU5F1 (OCT4), RUNX1 (AML1), RUNX1T1, SUZ12, USP6, ARID2, ATM, CIC, CREBBP (CBP), CTNNB1, DICER1, EGFR (ERBB1), FBXW7, FLT3, H3-3A, MED12, MET, NCOR1, NOTCH2, PBRM1, SH2B3
Commercial Control Samples
ALK, BAIAP2L1, BRAF, CCDC6, CD74, EGFR (ERBB1), EML4, ERG, ETV6, FGFR3, KIF5B, LMNA, MET, NCOA4, NTRK1, NTRK3, PAX8, PPARG, RET, ROS1, SEPT14, SLC34A2, SLC45A3, TACC3, TFG, TMPRSS2, TPM3
General Sarcoma Markers
CD248, CD34, EGFR (ERBB1), ERG, MCAM, PDGFRA, PDGFRB, PROM1, S100A1, SOX2, TERT, VIM
Sarcoma Type & Subtype Markers
Alveolar Soft Part Sarcomas​
INHBA, TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas​
CAMTA1, DES, ERG, FOSB, MYC, PECAM1, TFE3
Chondrosarcomas​
AMACR, FLI1, SATB2, VEGFA
Dermatofibrosarcoma Protuberans​
GRIA2
Desmoplastic Small Round Cell Tumors​
WT1
Endometrial Stromal Sarcomas​
ACTA2 (α-SMA), BCOR, DES, EGFR (ERBB1), KIT (CD117)
Epitheliod Sarcomas​
CD109
Ewing's Sarcomas​
ALDH1A1 (RALDH1), ATP1A1, BCL11B, CCND1, CD99, FLI1, GLG1, NKX2-2, PAX7, RRM2, SLFN11, STEAP1, VEGFA
Fibromyxoid Sarcomas​
ANO1, MUC4
Follicular Dendritic Cell Sarcomas​
CLU, CR2, FCER2
Gastrointestinal Stromal Tumors (GIST)​
ACTA2 (α-SMA), ANO1, CALCRL, CD44, COL22A1, IGF1, IGF1R, IGF2, KIT (CD117), MUC4, PROM1, SDHA, SDHB
Gonadal Stromal Tumors​
CD99, INHBA, WT1
Intimal Sarcomas​
CDK4, MDM2, PDGFRA
Leiomyosarcomas​
ACTA2 (α-SMA), ANO1, DES
Liposarcomas​
CDK4, DES, MDM2
Malignant Peripheral Nerve Sheath Tumors (MPNST)​
ALK, BCL2, CDK4, GFAP, SMARCB1, SOX10, TLE1
Myofibroblastic Sarcomas​
ALK, BCL2, RB1
Myxofibrosarcomas​
AMACR, ASS1, CDK4, ITGA10, MDM2, MET
Osteosarcomas​
ALDH1A1 (RALDH1), CDK4, FLI1, LAMP3, MDM2, SATB2, VEGFA
Rhabdoid Tumors​
ETV4, SMARCB1
Rhabdomyosarcomas​
ACTA2 (α-SMA), ALDH1A1 (RALDH1), ALK, CDK4, DES, IGFBP2, MDM2, MYOD1, MYOG, PAX7
Solitary Fibrous Tumors​
ALDH1A1 (RALDH1), GRIA2, STAT6
Spindle Cell Sarcomas​
AFAP1L1
Synovial Sarcomas​
ANO1, BCL2, CDCA2, EZH2, FLI1, INHBA, KIF14, MUC4, PAX7, TLE1
Undifferentiated; Unclassified or Other Sarcomas​
CCNB3, SOX10, WT1
Possible Prognostic Significance
Associated with Invasiveness​
CD44, PROM1, STEAP1, TERT
Associated with Metastasis​
ACKR3, CD9, CDCA2, CTAG1B, CXCR4, EZH2, IGFBP7, ITGA10, KIF14
Chemotherapy Resistance​
ALDH1A1 (RALDH1), AMACR, CEBPB, PDGFRA, PDGFRB, STEAP1
Clinical Outcome or Tumor Grade Indicators​
AFAP1L1, AMACR, CD109, CD274 (PD-L1), CD274 (PD-L1), CD44, CD9, CDCA2, CDK4, CTAG1B, CXCR4, EZH2, GPS2, IGF1R, IGFBP2, KIF14, MCAM, MDM2, STEAP1, TERT, VEGFA
Hypoxia & Oxidative Stress​
HIF1A, STEAP1, VEGFA
Immunotherapy Response​
CD274 (PD-L1), CD274 (PD-L1), CTAG1B
Treatment Targets or Treatment Indicators​
IGF1R, RRM2, SLFN11
Cancer Stem Cell & Proliferation Markers
ALDH1A1 (RALDH1), CD44, MKI67, PDGFRA, PDGFRB
Expression Affected by Genomic Variation
ALK, ATP1A1, BCL11B, BCOR, ERG, ETV4, FLI1, GLG1, NKX2-2, SOX2, WT1
Chordomas
ALK, APC, AR, ARID1A, ATM, CBL, CDKN2A (P16INK4A), CTNNB1, KIT (CD117), KMT2D, NRAS, PIK3CA (p110-alpha), PTEN, SMARCB1
Gastrointestinal Stromal Tumors (GIST)
ALK, APC, AR, ARID1A, ARID2, ASXL1, BRAF, CBL, CDKN2A (P16INK4A), CREBBP (CBP), DAXX, DICER1, EGFR (ERBB1), FBXW7, FGFR1, H3-3A, JAK1, KIT (CD117), KMT2D, KRAS, MED12, MYOD1, NOTCH2, PBRM1, PDGFRA, PIK3CA (p110-alpha), POLE, PTEN, RECQL4, SH2B3, TERT, TRAF7, ZFHX3
Kaposi Sarcomas
BRAF, PIK3CA (p110-alpha)
Malignant Peripheral Nerve Sheath Tumors (MPNST)
ARID2, BCOR, BRAF, CBL, CDKN2A (P16INK4A), KRAS, NRAS, PAX5, PDGFRA, TERT
Osteosarcomas
AKT1, ALK, APC, AR, ARID1A, ASXL1, BCOR, BRAF, CBL, CD209, CDKN2A (P16INK4A), CREBBP (CBP), DAXX, DNMT3A, EGFR (ERBB1), FBXW7, FGFR3, FGFR4, FLT3, GNAS, H3-3A, IDH2, JAK1, JAK3, KMT2D, MED12, MET, MLH1, MLLT3, NCOR1, NCOR2, NOTCH2, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), POLE, PTEN, RECQL4, SMAD2 (MADH2), TERT, TNC, TRRAP, WNK2, ZFHX3

Product Resources

Detailed Target List for each Analyte
File Size: 25.54 KBLanguage: English

Resources

Safety Data Sheets (1)
Kit Handbooks (1)
Template Files (1)
Certificates of Analysis (1)
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