Target List
Alveolar Soft Part Sarcomas
ASPSCR1, TFE3, APC, KMT2D, PTEN
Angiosarcomas & Epitheliod Haemangioendotheliomas
CAMTA1, CEP85L, CIC, LEUTX, ROS1, TFE3, YAP1, AKT1, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BRAF, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, HRAS, JAK3, KMT2D, KRAS, MED12, MET, MLH1, MPL, NCOR1, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, PTEN, TERT, TRAF7, TRRAP, ZFHX3
Askins Tumors
ERG, EWSR1, FLI1, FUS
Chondrosarcomas
ACVR2A, CDX1, EWSR1, FN1, HEY1, IRF2BP2, NCOA2, NR4A3 (NOR1), TAF15, TCF12, TFG, ALK, AR, ARID1A, CDKN2A (P16INK4A), DNMT3A, ERBB3, H3-3A, HRAS, IDH1, IDH2, IRS4, JAK1, KMT2D, MLLT3, NRAS, POLE, PTEN, SMAD2 (MADH2), SMARCB1, TERT, ZFHX3
Clear Cell Sarcomas
ATF1, CREB1, EWSR1, FLI1, NUTM2B, YWHAE, BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), NRAS, PTEN
Congenital (Infantile) Fibrosarcomas
ETV6, MET, NTRK3, TFG
Dermatofibrosarcoma Protuberans
COL1A1, PDGFB, FGFR1, MED12
Dermatofibrosarcomas Protuberans
COL1A1, PDGFB
Desmoplastic Small Round Cell Tumors
ERG, EWSR1, FLI1, PATZ1, WT1, APC, CIC, CREBBP (CBP), DAXX, EGFR (ERBB1)
Endometrial Stromal Sarcomas
ALK, BCOR, CXorf67, EPC1, FN1, JAZF1, MBTD1, MEAF6, NUTM2A, NUTM2B, PHF1, SUZ12, YWHAE, ZC3H7B, ASXL1, CTNNB1, ERBB3, FBXW7, FGFR2, FLT3, KRAS, MED12, PIK3CA (p110-alpha)
Epithelioid Sarcomas
CREB3L1, CREB3L2, EWSR1, FUS, KLF17, SS18, SSX1, DICER1, SMARCB1
Ewing's Sarcomas
CIC, ERG, ETV1, ETV4, EWSR1, FEV, FLI1, FOXO4, FUS, NFATC2, SMARCA5, SP3, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BCOR, BRAF, CBL, CD209, CD79B, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, DAXX, DGCR8, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), EZH2, FBXW7, FGFR1, FGFR3, FGFR4, GNAS, HRAS, IDH1, IDH2, IRS4, KIT (CD117), KMT2D, KRAS, MED12, MET, MLH1, MLLT3, MYOD1, NCOR1, NCOR2, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, POLE, PTEN, RECQL4, SMARCB1, TERT, TNC, TRAF7, TRRAP, ZFHX3
Fibrosarcomas
BRAF, COL1A1, CREB3L1, CREB3L2, EWSR1, FUS, LMNA, NTRK1, PDGFB, TOM1L2, BCOR, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), EZH2, FGFR3, FLT3, KIT (CD117), KRAS, NRAS, POLE, PTEN, TERT, TRAF7
Leiomyosarcomas
EWSR1, HMGA2, PBX3, WT1, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, CBL, CREBBP (CBP), DAXX, DNMT3A, ERBB3, EZH2, FGFR1, FGFR3, JAK1, JAK3, MET, MPL, NCOR1, PAX5, RECQL4, TRAF7
Liposarcomas
DDIT3 (GADD153, CHOP), EWSR1, FUS, HMGA2, LGR5, NUP107, AKT1, ALK, APC, ARID1A, ATM, BRAF, CBL, CD79B, CDKN2A (P16INK4A), CIC, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), FBXW7, FGFR1, FGFR2, FGFR3, HRAS, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MLH1, MPL, NCOR1, NOTCH2, PBRM1, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), POLE, PTEN, RECQL4, TERT, ZFHX3
Myofibroblastic Sarcomas
ALK, LMNA, NTRK1, RELA, ROS1, SRF, TFG, TPM3, YWHAE
Myxofibrosarcomas
CREB3L1, CREB3L2, FUS
Myxoid Chondrosarcomas
NR4A3 (NOR1), TAF15
Perivascular Epithelioid Cell Tumors (PEComa)
DVL2, SFPQ, TFE3, ALK, ATM, CIC, JAK3, MED12, NOTCH2
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)
CITED2, MED12, PRDM10, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BRAF, CD79B, CDKN2A (P16INK4A), CIC, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR4, FLT3, HRAS, IDH1, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MET, MLH1, MYOD1, NCOR1, NOTCH2, NRAS, PAX5, PBRM1, PIK3CA (p110-alpha), POLE, PTEN, PTPN11, SMARCB1, TERT, TRAF7, ZFHX3
Rhabdoid Tumors
NCOA4, RET, CREBBP (CBP), PBRM1, SMARCB1
Rhabdomyosarcomas
CITED2, EWSR1, FLI1, FOXO1, NCOA1, NCOA2, PAX3, PAX7, SRF, TEAD1, VGLL2, ALK, APC, AR, ARID1A, ARID2, ASXL1, ATM, BCOR, BRAF, CDKN2A (P16INK4A), CIC, CREBBP (CBP), CTNNB1, DAXX, DGCR8, DICER1, DNMT3A, ERBB2 (HER-2, NEU), ERBB3, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GNAS, HRAS, IRS4, KIT (CD117), KMT2D, KRAS, MED12, MET, MLH1, MPL, MYOD1, NCOR2, NOTCH2, NRAS, PDGFRA, PIK3CA (p110-alpha), POLE, PTEN, PTPN11, RECQL4, SH2B3, SMARCB1, TNC, TRAF7, TRRAP, WNK2, ZFHX3
Small Round Cell Tumors
ERG, ETV1, EWSR1, FEV, FLI1, FOXO1, PAX3
Solitary Fibrous Tumors
NAB2, STAT6, ALK, APC, ARID2, CBL, FBXW7, FGFR1, FGFR3, KMT2D, PIK3R1 (p85-ALPHA), PTEN, TERT
Synovial Sarcomas
COL6A3, CSF1 (MCSF), S100A10, SS18, SS18L1, SSX1, SSX2, SSX4B, ARID2, BCOR, BRAF, CTNNB1, EGFR (ERBB1), FGFR1, HRAS, KMT2D, KRAS, MED12, MLH1, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, TERT, TRAF7, TRRAP, ZFHX3
Undifferentiated; Unclassified or Other Sarcomas
ATF1, BCOR, CCNB3, CREM, ERG, ETV4, EWSR1, FGF1, FGFR1, FLI1, FN1, FOXO1, FUS, GLI1, JAZF1, MAML3, MKL2, NPM1, PAX3, PLAG1, POU5F1 (OCT4), RUNX1 (AML1), RUNX1T1, SUZ12, USP6, ARID2, ATM, CIC, CREBBP (CBP), CTNNB1, DICER1, EGFR (ERBB1), FBXW7, FLT3, H3-3A, MED12, MET, NCOR1, NOTCH2, PBRM1, SH2B3
Commercial Control Samples
ALK, BAIAP2L1, BRAF, CCDC6, CD74, EGFR (ERBB1), EML4, ERG, ETV6, FGFR3, KIF5B, LMNA, MET, NCOA4, NTRK1, NTRK3, PAX8, PPARG, RET, ROS1, SEPT14, SLC34A2, SLC45A3, TACC3, TFG, TMPRSS2, TPM3
General Sarcoma Markers
CD248, CD34, EGFR (ERBB1), ERG, MCAM, PDGFRA, PDGFRB, PROM1, S100A1, SOX2, TERT, VIM
Sarcoma Type & Subtype Markers
Alveolar Soft Part Sarcomas
INHBA, TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas
CAMTA1, DES, ERG, FOSB, MYC, PECAM1, TFE3
Chondrosarcomas
AMACR, FLI1, SATB2, VEGFA
Dermatofibrosarcoma Protuberans
GRIA2
Desmoplastic Small Round Cell Tumors
WT1
Endometrial Stromal Sarcomas
ACTA2 (α-SMA), BCOR, DES, EGFR (ERBB1), KIT (CD117)
Epitheliod Sarcomas
CD109
Ewing's Sarcomas
ALDH1A1 (RALDH1), ATP1A1, BCL11B, CCND1, CD99, FLI1, GLG1, NKX2-2, PAX7, RRM2, SLFN11, STEAP1, VEGFA
Fibromyxoid Sarcomas
ANO1, MUC4
Follicular Dendritic Cell Sarcomas
CLU, CR2, FCER2
Gastrointestinal Stromal Tumors (GIST)
ACTA2 (α-SMA), ANO1, CALCRL, CD44, COL22A1, IGF1, IGF1R, IGF2, KIT (CD117), MUC4, PROM1, SDHA, SDHB
Gonadal Stromal Tumors
CD99, INHBA, WT1
Intimal Sarcomas
CDK4, MDM2, PDGFRA
Leiomyosarcomas
ACTA2 (α-SMA), ANO1, DES
Liposarcomas
CDK4, DES, MDM2
Malignant Peripheral Nerve Sheath Tumors (MPNST)
ALK, BCL2, CDK4, GFAP, SMARCB1, SOX10, TLE1
Myofibroblastic Sarcomas
ALK, BCL2, RB1
Myxofibrosarcomas
AMACR, ASS1, CDK4, ITGA10, MDM2, MET
Osteosarcomas
ALDH1A1 (RALDH1), CDK4, FLI1, LAMP3, MDM2, SATB2, VEGFA
Rhabdoid Tumors
ETV4, SMARCB1
Rhabdomyosarcomas
ACTA2 (α-SMA), ALDH1A1 (RALDH1), ALK, CDK4, DES, IGFBP2, MDM2, MYOD1, MYOG, PAX7
Solitary Fibrous Tumors
ALDH1A1 (RALDH1), GRIA2, STAT6
Spindle Cell Sarcomas
AFAP1L1
Synovial Sarcomas
ANO1, BCL2, CDCA2, EZH2, FLI1, INHBA, KIF14, MUC4, PAX7, TLE1
Undifferentiated; Unclassified or Other Sarcomas
CCNB3, SOX10, WT1
Possible Prognostic Significance
Associated with Invasiveness
CD44, PROM1, STEAP1, TERT
Associated with Metastasis
ACKR3, CD9, CDCA2, CTAG1B, CXCR4, EZH2, IGFBP7, ITGA10, KIF14
Chemotherapy Resistance
ALDH1A1 (RALDH1), AMACR, CEBPB, PDGFRA, PDGFRB, STEAP1
Clinical Outcome or Tumor Grade Indicators
AFAP1L1, AMACR, CD109, CD274 (PD-L1), CD274 (PD-L1), CD44, CD9, CDCA2, CDK4, CTAG1B, CXCR4, EZH2, GPS2, IGF1R, IGFBP2, KIF14, MCAM, MDM2, STEAP1, TERT, VEGFA
Hypoxia & Oxidative Stress
HIF1A, STEAP1, VEGFA
Immunotherapy Response
CD274 (PD-L1), CD274 (PD-L1), CTAG1B
Treatment Targets or Treatment Indicators
IGF1R, RRM2, SLFN11
Cancer Stem Cell & Proliferation Markers
ALDH1A1 (RALDH1), CD44, MKI67, PDGFRA, PDGFRB
Expression Affected by Genomic Variation
ALK, ATP1A1, BCL11B, BCOR, ERG, ETV4, FLI1, GLG1, NKX2-2, SOX2, WT1
Chordomas
ALK, APC, AR, ARID1A, ATM, CBL, CDKN2A (P16INK4A), CTNNB1, KIT (CD117), KMT2D, NRAS, PIK3CA (p110-alpha), PTEN, SMARCB1
Gastrointestinal Stromal Tumors (GIST)
ALK, APC, AR, ARID1A, ARID2, ASXL1, BRAF, CBL, CDKN2A (P16INK4A), CREBBP (CBP), DAXX, DICER1, EGFR (ERBB1), FBXW7, FGFR1, H3-3A, JAK1, KIT (CD117), KMT2D, KRAS, MED12, MYOD1, NOTCH2, PBRM1, PDGFRA, PIK3CA (p110-alpha), POLE, PTEN, RECQL4, SH2B3, TERT, TRAF7, ZFHX3
Kaposi Sarcomas
BRAF, PIK3CA (p110-alpha)
Malignant Peripheral Nerve Sheath Tumors (MPNST)
ARID2, BCOR, BRAF, CBL, CDKN2A (P16INK4A), KRAS, NRAS, PAX5, PDGFRA, TERT
Osteosarcomas
AKT1, ALK, APC, AR, ARID1A, ASXL1, BCOR, BRAF, CBL, CD209, CDKN2A (P16INK4A), CREBBP (CBP), DAXX, DNMT3A, EGFR (ERBB1), FBXW7, FGFR3, FGFR4, FLT3, GNAS, H3-3A, IDH2, JAK1, JAK3, KMT2D, MED12, MET, MLH1, MLLT3, NCOR1, NCOR2, NOTCH2, PBRM1, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), POLE, PTEN, RECQL4, SMAD2 (MADH2), TERT, TNC, TRRAP, WNK2, ZFHX3