Target List
Exons
NRAS, PDGFRA, PIK3CA, PMS2CL
Exons & Hotspots
PMS2
Hotspots
ABL1, AKT1, ALB, ALK, APOB, AR, ARAF, ARID1A, ARID2, ATM, AXIN1, BRAF, CCND1, CCNE1, CDH1, CDKN2A, CHEK2, CREBBP, CSF1R, CSF3R, CTNNB1, DPYD, ERBB3, ERCC1, ERCC2, ESR1, EZH2, FANCM, FBXW7, FGFR2, FGFR3, FLT3, FOXA1, FOXL2, GNAS, HRAS, IDH1, IDH2, JAK1, JAK2, KDM6A, KEAP1, KMT2D, MAP2K1, MAPK1, MED12, MPL, MSH6, MYC, MYD88, NF2, NFE2L2, NOTCH1, NTRK1, PIK3R1, POLE, PPP2R1A, PTPN11, RB1, RET, RIT1, RNF43, ROS1, RRAS, RRAS2, RUNX1, SF3B1, SMAD4, SPOP, SRSF2, STAT3, STK11, TCF7L2, TGFBR2, TSC2, U2AF1, UGT1A1
Promoter
TERT
Promoter & Hotspots
APC, MLH1, MSH2, PTEN
Whole Coding
BRCA1, BRCA2, EGFR, ERBB2, KRAS, MET, TP53
Bladder Cancers
AKT1, ARID1A, ATM, BRAF, CCND1, CCNE1, CDKN2A, CTNNB1, ERBB2, ERBB3, ERCC2, FGFR2, FGFR3, HRAS, JAK2, KDM6A, KRAS, MPL, PIK3CA, PTEN, RB1, TP53, U2AF1
Brain Cancers
ALK, APC, BRAF, BRCA2, CDKN2A, CHEK2, CREBBP, CTNNB1, EGFR, ERBB2, FGFR3, IDH1, IDH2, KIT, KRAS, MET, MLH1, MSH2, MYC, NF2, NOTCH1, NRAS, PDGFRA, PIK3CA, PMS2, PMS2CL, PTEN, PTPN11, RB1, STK11, TERT, TP53
Breast Cancers
AKT1, AR, ARAF, ATM, BRCA1, BRCA2, CCND1, CDH1, CHEK2, EGFR, ERBB2, ERBB3, ESR1, FBXW7, FGFR2, FLT3, JAK2, KIT, KRAS, MET, MLH1, MPL, MSH2, MSH6, MYC, PDGFRA, PIK3CA, PMS2, PMS2CL, PPP2R1A, PTEN, RUNX1, SF3B1, STK11, TP53, U2AF1
Cervical Cancers
ARAF, MAPK1, MPL
Colorectal Cancers
AKT1, APC, ARID1A, ATM, BRAF, BRCA1, BRCA2, CDKN2A, CHEK2, CSF1R, CTNNB1, DPYD, EGFR, ERBB2, ERBB3, ERCC1, ESR1, FBXW7, FGFR3, FLT3, GNAS, HRAS, JAK2, KIT, KRAS, MAP2K1, MET, MLH1, MPL, MSH2, MSH6, MYC, NRAS, PDGFRA, PIK3CA, PMS2, PMS2CL, POLE, PTEN, RET, RNF43, SMAD4, SRSF2, STK11, TCF7L2, TGFBR2, TP53, UGT1A1
Gastric Cancers
APC, ARAF, ARID1A, BRAF, CDH1, CDKN2A, CTNNB1, ERBB2, ERBB3, FBXW7, GNAS, JAK2, KIT, KMT2D, KRAS, MET, MPL, MYC, PDGFRA, PIK3CA, PTEN, RNF43, SMAD4, SRSF2, TP53
Liver Cancers
ALB, APC, APOB, ARID1A, ARID2, AXIN1, BRAF, CCND1, CDKN2A, CREBBP, CTNNB1, IDH1, IDH2, JAK1, JAK2, KEAP1, KRAS, MYC, NFE2L2, NRAS, PIK3CA, RB1, RIT1, TP53, TSC2
Lung Cancers
ABL1, AKT1, ALK, ARAF, ATM, BRAF, BRCA1, BRCA2, CCND1, CDKN2A, CHEK2, CSF3R, CTNNB1, EGFR, ERBB2, FGFR3, FLT3, HRAS, IDH1, JAK2, KIT, KRAS, MAP2K1, MET, MLH1, MPL, MSH2, MSH6, MYC, NF2, NRAS, NTRK1, PDGFRA, PIK3CA, PMS2, PMS2CL, PTEN, RB1, RET, ROS1, RRAS, STK11, TP53, TSC2, U2AF1
Lymphomas
ARID1A, ATM, BRAF, CCND1, CDKN2A, CHEK2, CREBBP, EZH2, GNAS, IDH1, IDH2, JAK1, KMT2D, MAP2K1, MYC, MYD88, NOTCH1, NRAS, PIK3CA, SF3B1, STAT3, TP53
Melanomas
ARID2, ATM, BRAF, BRCA1, BRCA2, CCND1, CDKN2A, CHEK2, CREBBP, CTNNB1, EGFR, EZH2, HRAS, IDH1, KIT, KRAS, MAP2K1, MLH1, MSH2, MSH6, NRAS, PDGFRA, PIK3CA, PTEN, RB1, TP53
Ovarian Cancers
AKT1, ARID1A, ATM, BRAF, BRCA1, BRCA2, CCND1, CCNE1, CDH1, CDKN2A, CHEK2, CTNNB1, ERBB2, ERBB3, ERCC1, FANCM, FBXW7, FGFR2, FGFR3, FOXL2, KIT, KRAS, MLH1, MPL, MSH2, MSH6, MYC, PDGFRA, PIK3CA, PIK3R1, PMS2, PMS2CL, POLE, PPP2R1A, PTEN, RB1, RRAS2, STK11, TP53
Pancreatic Cancers
APC, ARID1A, ATM, BRAF, BRCA1, BRCA2, CDKN2A, CTNNB1, ERBB2, ERBB3, FBXW7, GNAS, JAK2, KDM6A, KRAS, MET, MLH1, MSH2, MSH6, MYC, NRAS, PIK3CA, PMS2, PMS2CL, POLE, PTEN, RNF43, SMAD4, STK11, TCF7L2, TP53, U2AF1
Prostate Cancers
AKT1, APC, AR, ARAF, ATM, BRAF, BRCA1, BRCA2, CHEK2, CTNNB1, FOXA1, HRAS, IDH1, JAK2, KDM6A, KMT2D, KRAS, MED12, MLH1, MPL, MSH2, MSH6, MYC, PIK3CA, PIK3R1, PMS2, PMS2CL, PTEN, RB1, SPOP, TP53, U2AF1