SEPTIN10
SEPTIN10 Gene Summary
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | SEPTIN10 |
| Official Name | septin 10 [Source:HGNC Symbol;Acc:HGNC:14349] |
| Ensembl ID | ENSG00000186522 |
| Bio databases IDs | |
| Aliases | septin 10, sept1-like |
| Synonyms | 4921515A04Rik,9430099J10RIK,FLJ11619,LOC309891,SEPT10 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of Unknown Function (DUF349)
- transcription regulator
- UDM1_RNF168_RNF169-like
- protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the SEPTIN10 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- SLC3A2
- ENTR1
- RAC1
- DDX39A
- XPO1
- SEPTIN9
- SEPTIN2
- SEPTIN7
- ADARB1
disease
- COVID-19
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
regulated by
- lipopolysaccharide
- LIPA
- cephaloridine
- topotecan
- LAMA4
- TBX2
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm annulus
- Nucleus
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SEPTIN10 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein localization
CELLULAR COMPONENT
Where in the cell the gene product is active
- microtubule cytoskeleton
- motile cilium
- cell division site
- septin complex
- septin ring
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging