XPO1 Gene Summary [Human]
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
Details
| Type | Retained Intron |
| Official Symbol | XPO1 |
| Official Name | exportin 1 [Source:HGNC Symbol;Acc:HGNC:12825] |
| Ensembl ID | ENSG00000082898 |
| Bio databases IDs | |
| Aliases | exportin 1, chromosome region maintenance 1 homolog (yeast) |
| Synonyms | CRM-1, CRMA, emb, Exp1, Exportin-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XPO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CRM1 / Exportin repeat 2
- CRM1 / Exportin repeat 3
- Chromosome region maintenance or exportin repeat
- Exportin 1-like protein
- central domain
- transcription factor binding
- protein domain specific binding
- protein binding
- Importin-beta N-terminal domain
- nuclear export signal receptor
- CRM1 C terminal
- transporter
Pathways
Biological processes and signaling networks where the XPO1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- non-Hodgkin lymphoma
- lymphoma
- acute myeloid leukemia
- refractory diffuse large B-cell lymphoma
- endometrial serous carcinoma
- uterine endometrioid carcinoma
- metastatic endometrial cancer
- esophageal squamous cell carcinoma
role in cell
- expression in
- differentiation
- phosphorylation in
- apoptosis
- activation in
- growth
- cell death
- size
- cell viability
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- endomembrane system
- Cytoplasm
- centrosome
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear envelope
- Cajal bodies
- kinetochores
- centrosomal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XPO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit export from nucleus
- mRNA export from nucleus
- nucleocytoplasmic transport
- ribosomal large subunit export from nucleus
- ribosomal subunit export from nucleus
- regulation of centrosome duplication
- ribosome biogenesis
- protein export from nucleus
- regulation of protein export from nucleus
- protein localization to nucleus
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- Cajal body
- kinetochore
- nucleolus
- annulate lamellae
- nucleoplasm
- nuclear envelope
- nucleus
- nuclear membrane
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- small GTPase binding
- nuclear export signal receptor activity