KDM5D Gene Summary [Human]
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Details
| Type | Retained Intron |
| Official Symbol | KDM5D |
| Official Name | lysine demethylase 5D [Source:HGNC Symbol;Acc:HGNC:11115] |
| Ensembl ID | ENSG00000012817 |
| Bio databases IDs | |
| Aliases | lysine demethylase 5D |
| Synonyms | H-Y, HYA, JARID1D, Lysine demethylase 5D, SMCY |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM5D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C5HC2 zinc finger
- PHD zinc finger
- jmjN domain
- PLU-1-like protein
- androgen receptor binding
- PHD finger superfamily
- enzyme
- protein binding
- RmlC-like cupin superfamily
- ARID/BRIGHT DNA binding domain
- histone demethylase activity
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- severe acute respiratory syndrome
- breast adenocarcinoma
- idiopathic inflammatory myopathy
- autism
- systemic lupus erythematosus
regulated by
- PRKCSH
- NEF
- CD3 (complex)
regulates
- DNA promoter
- DNA endogenous promoter
- MYBL2
- histone H3
role in cell
- trimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM5D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell antigen processing and presentation
- chromatin remodeling
- regulation of transcription, DNA-dependent
- regulation of androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- androgen receptor binding
- metal ion binding
- histone demethylase activity
- histone demethylase activity (H3-K4 specific)
- histone demethylase activity (H3-trimethyl-K4 specific)