USP18 Gene Summary [Human]
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | USP18 |
| Official Name | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] |
| Ensembl ID | ENSG00000184979 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 18, Ubl carboxyl-terminal hydrolase 18 |
| Synonyms | 1110058H21Rik, ISG43, LOC100359614, PTORCH2, ubiquitin specific peptidase 18, Ubp15, UBP43 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ISG15-specific protease
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP18 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- pseudo-TORCH syndrome type 2
- diabetes mellitus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- autoimmune inflammation
- dilated cardiomyopathy
- hydrocephalus
- cardiac fibrosis
- ventricular dilatation
role in cell
- expression in
- activation in
- replication in
- phosphorylation in
- apoptosis
- production in
- cell viability
- migration
- growth
- focal necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- response to bacterium
- proteolysis
- regulation of inflammatory response
- negative regulation of type I interferon-mediated signaling pathway
- response to stilbenoid
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ISG15-specific protease activity
- binding, bridging