MYBL2 Gene Summary [Human]
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | MYBL2 |
| Official Name | MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548] |
| Ensembl ID | ENSG00000101057 |
| Bio databases IDs | |
| Aliases | MYB proto-oncogene like 2 |
| Synonyms | B-MYB, MYBB, MYB proto-oncogene like 2, MYB-Related Protein B, myeloblastosis oncogene-like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYBL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- regulatory domain
- DNA binding domain
- nucleic acid binding
- negative regulatory domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- C-myb, C-terminal
- acidic domain
- Myb repeat
- phosphorylation site
- conserved domain
- double-stranded DNA binding
- Myb-like DNA-binding domain
- GT1, myb-like, SANT family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- cancer
- liver cancer
- hepatocellular carcinoma
- prostate cancer
- metastasis
- colorectal cancer
- renal clear cell adenocarcinoma
role in cell
- activation in
- migration
- expression in
- apoptosis
- production in
- phosphorylation in
- proliferation
- survival
- adhesion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYBL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Myb complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity