Chd6 Gene Summary [Rat]
Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and transcription coregulator binding activity. Predicted to be involved in cell redox homeostasis; chromatin remodeling; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Orthologous to human CHD6 (chromodomain helicase DNA binding protein 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chd6 |
| Official Name | chromodomain helicase DNA binding protein 6 [Source:RGD Symbol;Acc:1310465] |
| Ensembl ID | ENSRNOG00000016744 |
| Bio databases IDs | |
| Aliases | chromodomain helicase DNA binding protein 6 |
| Synonyms | 5430439G14RIK, 6330406J24Rik, CHD5, chromodomain helicase DNA binding protein 6, KIAA1335, RIGB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- DEAD/DEAH box helicase
- SNF2-related domain
- helicase superfamily c-terminal domain
- transcription factor binding
- enzyme
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- BRK domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- ETGE motif
- DEAD-like helicases superfamily
- Chromo (CHRromatin organization MOdifier) domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric adenocarcinoma
- gastric epithelial cancer
- major depression
- motor dysfunction or movement disorder
- astigmatism
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hippocampal atrophy
- urothelial neoplasm
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of gene expression
- cell redox homeostasis
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- transcription cofactor binding
- ATP binding
- DNA-dependent ATPase activity
- histone binding
- helicase activity
- chromatin binding