Tcf7

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; cellular response to interleukin-4; and regulation of gamma-delta T cell differentiation. Predicted to act upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Predicted to be located in euchromatin and nuclear body. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Orthologous to human TCF7 (transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tcf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tcf7 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Tcf7 gene, providing context for its role in the cell.