Larp7 Gene Summary [Rat]
Predicted to enable 7SK snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in several processes, including RNA processing; negative regulation of viral transcription; and regulation of RNA metabolic process. Predicted to act upstream of or within germ cell proliferation; negative regulation of transcription by RNA polymerase II; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of 7SK snRNP. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Larp7 |
| Official Name | La ribonucleoprotein 7, transcriptional regulator [Source:RGD Symbol;Acc:1592474] |
| Ensembl ID | ENSRNOG00000048989 |
| Bio databases IDs | |
| Aliases | La ribonucleoprotein 7, transcriptional regulator |
| Synonyms | ALAZS, C330027G06RIK, D3Wsu161e, DKFZp564K112, HDCMA18P, hLARP7, La ribonucleoprotein 7, transcriptional regulator, PIP7S |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Larp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- RNA recognition motif (RRM) superfamily
- La domain
- RNA recognition motif
- U6 snRNA binding
- protein binding
- RNA binding motif
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alazami syndrome
- gastric carcinoma
- gastric epithelial cancer
- mental retardation
role in cell
- binding
- synthesis in
- number
- proliferation
- binding in
- acetylation in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Larp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- box C/D snoRNA 3'-end processing
- RNA splicing
- negative regulation of transcription elongation from RNA polymerase II promoter
- spermatogenesis
- regulation of nuclear mRNA splicing, via spliceosome
- cell differentiation
- mRNA processing
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- U6 snRNA binding
- RNA binding
- protein binding
- mRNA binding