Cyp3a9 Gene Summary [Rat]
Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp3a9 |
| Official Name | cytochrome P450, family 3, subfamily a, polypeptide 9 [Source:RGD Symbol;Acc:708392] |
| Ensembl ID | ENSRNOG00000046643 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 3, subfamily a, polypeptide 9 |
| Synonyms | Cyp3a9, Cytochrome p450 3a9, cytochrome P450, family 3, subfamily a, polypeptide 13, cytochrome P450, family 3, subfamily a, polypeptide 9, IIIAm2, P450olf3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp3a9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- enzyme binding
- iron ion binding
- enzyme
- steroid hydroxylase
- CH2 group oxidoreductase
- steroid binding
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- vitamin D3 25-hydroxylase
- reduced flavin or flavoprotein:oxygen oxidoreductase
- testosterone 6 beta-hydroxylase
- retinoic acid 4-hydroxylase
- monooxygenase
Pathways
Biological processes and signaling networks where the Cyp3a9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum membrane