Nr1i3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in osteoblast differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Biomarker of cholestasis. Orthologous to human NR1I3 (nuclear receptor subfamily 1 group I member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr1i3 |
| Official Name | nuclear receptor subfamily 1, group I, member 3 [Source:RGD Symbol;Acc:621400] |
| Ensembl ID | ENSRNOG00000003260 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1, group I, member 3 |
| Synonyms | CAR, CAR1, CAR2, CAR-beta, Care2, CAR-β, Constitutive androstane receptor, ESTM32, MB67, nuclear receptor subfamily 1 group I member 3, nuclear receptor subfamily 1, group I, member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nr1i3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- dimerization domain
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- alpha helix
- xenobiotic response sequence
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nr1i3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cancer
- obesity
- hepatic steatosis
- diabetic nephropathy
- hepatomegaly
- hepatic injury
- survival
- weight loss
- leukopenia
role in cell
- proliferation
- activation in
- binding in
- expression in
- induction in
- apoptosis
- development
- recruitment in
- transactivation in
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nr1i3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- signal transduction
- cell differentiation
- osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity