Cideb Gene Summary [Mouse]
Enables lipid transfer activity; molecular adaptor activity; and phosphatidic acid binding activity. Involved in several processes, including COPII-coated vesicle cargo loading; lipid droplet fusion; and very-low-density lipoprotein particle assembly. Part of COPII vesicle coat. Is active in Golgi apparatus; endoplasmic reticulum membrane; and lipid droplet. Is expressed in autopod; dorsal root ganglion; and urinary system. Orthologous to human CIDEB (cell death inducing DFFA like effector b). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cideb |
| Official Name | cell death-inducing DNA fragmentation factor, alpha subunit-like effector B [Source:MGI Symbol;Acc:MGI:1270844] |
| Ensembl ID | ENSMUSG00000022219 |
| Bio databases IDs | |
| Aliases | cell death-inducing DNA fragmentation factor, alpha subunit-like effector B |
| Synonyms | 1110030C18Rik, AI790179, cell death-inducing DFFA-like effector b, cell death-inducing DNA fragmentation factor, alpha subunit-like effector B, cell death-inducing DNA fragmentation factor, α subunit-like effector B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cideb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- binding protein
- CIDE-N domain
- alpha helix
- CIDE_N
- protein binding
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hepatic steatosis
role in cell
- growth
- accumulation in
- apoptosis
- buildup
- fusion
- size
- buildup in
- activity
- fusion in
- budding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- VLDL transport vesicle
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- lipid droplet contact site
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cideb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- apoptotic process
- positive regulation of apoptotic process
- cargo loading into COPII-coated vesicle
- very-low-density lipoprotein particle assembly
- regulation of apoptotic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- response to nutrient levels
- execution phase of apoptosis
- regulation of triglyceride metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- perinuclear region of cytoplasm
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- COPII vesicle coat
- COPI-coated vesicle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- phosphatidic acid binding
- binding, bridging