Plin2 Gene Summary [Mouse]
Acts upstream of or within lipid storage and long-chain fatty acid transport. Located in several cellular components, including cytosol; lipid droplet; and nucleus. Is expressed in hindlimb tendon and pancreas epithelium. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Plin2 |
| Official Name | perilipin 2 [Source:MGI Symbol;Acc:MGI:87920] |
| Ensembl ID | ENSMUSG00000028494 |
| Bio databases IDs | |
| Aliases | perilipin 2 |
| Synonyms | ADFP, Adipophilin, Adipose differentiation-related, ADPH, ADRP, perilipin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Perilipin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- epithelial cancer
- lung adenocarcinoma
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatocellular carcinoma
- liver cancer
- atherosclerosis
- glioblastoma
role in cell
- expression in
- formation
- hydrolysis in
- activation in
- growth
- size
- accumulation in
- oxidation in
- accumulation
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- membrane fraction
- lipid-rich fraction
- lipid droplet surface
- Cytoplasm
- Extracellular Space
- membrane surface
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- retinosome
- lipid droplets
- cytosol
- apical cell surfaces
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- long-chain fatty acid transport
- response to xenobiotic stimulus
- response to organic cyclic compound
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytosol
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding