Rab2a Gene Summary [Mouse]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in macroautophagy. Located in Golgi apparatus and autophagosome membrane. Is expressed in dorsal root ganglion; eye; foregut; limb; and limb mesenchyme. Orthologous to human RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab2a |
| Official Name | RAB2A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1928750] |
| Ensembl ID | ENSMUSG00000047187 |
| Bio databases IDs | |
| Aliases | RAB2A, member RAS oncogene family |
| Synonyms | 9330148M11Rik, LHX, RAB2, RAB2A, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- alpha helix
- aPKC binding domain
- GTPase
- enzyme
- guanine nucleotide binding domain
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- GTP binding
- nucleotide-binding domain
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- rheumatoid arthritis
- autoimmune thyroid disease
- neonatal late-onset sepsis
- infection by HIV-1
regulated by
- geranylgeranyl pyrophosphate
- ethanol
- beta-estradiol
- hematopoietic progenitor cells
- testosterone
- dihydrotestosterone
- T lymphocytes
- FSH
- PPARA
- fulvestrant
role in cell
- expression in
- accumulation in
- hypertrophy
- formation
- accumulation
- vesiculation
- fragmentation
- organization
- fragmentation in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- synaptic vesicle membrane
- perinuclear region
- cellular membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- autophagic vacuoles
- peroxisomes
- perikaryon
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- vesicle-mediated transport
- Golgi organization
- protein transport
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular vesicular exosome
- melanosome
- acrosomal vesicle
- cytosol
- Golgi membrane
- Golgi apparatus
- lysosomal membrane
- autophagic vacuole membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding