Il13 Gene Summary [Mouse]
Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within several processes, including positive regulation of immune effector process; response to nematode; and response to selenium ion. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il13 |
| Official Name | interleukin 13 [Source:MGI Symbol;Acc:MGI:96541] |
| Ensembl ID | ENSMUSG00000020383 |
| Bio databases IDs | |
| Aliases | interleukin 13 |
| Synonyms | ALRH, interleukin 13, P600 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-13 receptor binding
- Interleukin 4
- protein binding
- cytokine
- Interleukin-13
Pathways
Biological processes and signaling networks where the Il13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- infection
- hyperplasia
- skin cancer
- psoriasis
- mastocytosis
- experimental autoimmune encephalomyelitis
- hepatic steatosis
- asthma
- Down syndrome
phenotypes
- decreased bronchoconstrictive response
- decreased monocyte cell number
- decreased pulmonary respiratory rate
- increased pulmonary ventilation
- abnormal T-helper 2 cell differentiation
- abnormal T-helper 2 physiology
- abnormal antigen presentation
- abnormal chemokine level
- abnormal dendritic cell antigen presentation
- abnormal dendritic cell differentiation
- abnormal immune system physiology
- abnormal interleukin secretion
- abnormal interleukin-4 secretion
- abnormal intestinal goblet cell morphology
- abnormal leukocyte physiology
- abnormal macrophage physiology
- abnormal mammary gland growth during pregnancy
- abnormal respiration
- abnormal response to injury
- abnormal response to transplant
- abnormal splenocyte physiology
- abnormal type I hypersensitivity reaction
- altered susceptibility to infection
- decreased IgE level
- decreased IgG level
- decreased IgG1 level
- decreased T-helper 2 cell number
- decreased circulating interleukin-13 level
- decreased eosinophil cell number
- decreased inflammatory response
- decreased interferon-gamma secretion
- decreased interleukin-10 secretion
- decreased interleukin-13 secretion
- decreased interleukin-4 secretion
- decreased interleukin-5 secretion
- decreased interleukin-9 secretion
- decreased macrophage cell number
- decreased susceptibility to autoimmune disorder
- decreased susceptibility to bacterial infection
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to injury
- decreased susceptibility to parasitic infection
- decreased susceptibility to parasitic infection induced morbidity/mortality
- granulomatous inflammation
- ileum inflammation
- impaired eosinophil recruitment
- impaired neutrophil recruitment
- increased IgG2a level
- increased IgG2b level
- increased IgM level
- increased circulating HDL cholesterol level
- increased eosinophil cell number
- increased interferon-gamma secretion
- increased length of allograft survival
- increased susceptibility to parasitic infection
- increased susceptibility to parasitic infection induced morbidity/mortality
- increased susceptibility to type I hypersensitivity reaction
- pulmonary fibrosis
role in cell
- quantity
- growth
- activation
- expression in
- proliferation
- differentiation
- apoptosis
- binding in
- activation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- plasma membrane extracellular face
- crystalloid granules
- specific granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell degranulation
- positive regulation of tyrosine phosphorylation of STAT protein
- macrophage activation
- positive regulation of smooth muscle cell proliferation
- response to ethanol
- inflammatory response
- immune response
- positive regulation of macrophage activation
- positive regulation of immunoglobulin production
- positive regulation of pancreatic stellate cell proliferation
- negative regulation of endothelial cell apoptotic process
- positive regulation of protein secretion
- regulation of proton transport
- positive regulation of connective tissue growth factor production
- negative regulation of transforming growth factor beta production
- signal transduction
- negative regulation of inflammatory response
- response to nicotine
- positive regulation of release of sequestered calcium ion into cytosol
- microglial cell activation
- cellular response to mechanical stimulus
- positive regulation of gene expression
- positive regulation of B cell proliferation
- cellular response to cytokine stimulus
- response to lipopolysaccharide
- positive regulation of interleukin-10 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-13 receptor binding
- cytokine activity