Sorcs1 Gene Summary [Mouse]
Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including frenulum; genitourinary system; nervous system; sensory organ; and visual system. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sorcs1 |
| Official Name | sortilin-related VPS10 domain containing receptor 1 [Source:MGI Symbol;Acc:MGI:1929666] |
| Ensembl ID | ENSMUSG00000043531 |
| Bio databases IDs | |
| Aliases | sortilin-related VPS10 domain containing receptor 1 |
| Synonyms | hSorCS, mSorCS, SORCS, sortilin-related VPS10 domain containing receptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sorcs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sortilin, neurotensin receptor 3, C-terminal
- Sortilin, neurotensin receptor 3,
- PKD domain
- VPS10 domain
- lumenal domain
- Cadherin repeat-like domain
- tail domain
- tyrosine internalization motif
- protein binding
- pro domain
- transmembrane receptor
- transporter
Pathways
Biological processes and signaling networks where the Sorcs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimers disease type 6
- insomnia
- colorectal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- uterine leiomyoma
- leiomyomatosis
role in cell
- accumulation in
- production in
- growth
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sorcs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- post-Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide receptor activity