Pgam2 Gene Summary [Mouse]
Enables phosphoglycerate mutase activity. Involved in canonical glycolysis. Acts upstream of or within Notch signaling pathway and glycolytic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgam2 |
| Official Name | phosphoglycerate mutase 2 [Source:MGI Symbol;Acc:MGI:1933118] |
| Ensembl ID | ENSMUSG00000020475 |
| Bio databases IDs | |
| Aliases | phosphoglycerate mutase 2 |
| Synonyms | D14Mgh1, GSD10, PGAM-M, Pgmut, Phosphoglycerate mutase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- bisphosphoglycerate phosphatase
- phosphoglycerate mutase
- phosphatase
- bisphosphoglycerate mutase
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Pgam2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glycogen storage disease type X
- chronic lymphocytic leukemia
- rhabdomyolysis
- Huntington disease
- systolic dysfunction
- organismal death
- amyotrophic lateral sclerosis
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- glycolysis in
- differentiation
- function
- gluconeogenesis in
- mitochondrial respiration in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- Notch signaling pathway
- spermatogenesis
- glycolysis
- response to mercury ion
- striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- bisphosphoglycerate mutase activity
- phosphoglycerate mutase activity
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
- hydrolase activity