Furin Gene Summary [Mouse]
This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Details
| Type | Retained Intron |
| Official Symbol | Furin |
| Official Name | furin (paired basic amino acid cleaving enzyme) [Source:MGI Symbol;Acc:MGI:97513] |
| Ensembl ID | ENSMUSG00000030530 |
| Bio databases IDs | |
| Aliases | furin (paired basic amino acid cleaving enzyme) |
| Synonyms | 9130404I01RIK, BASIC-AMINO-ACID-SPECIFIC FURIN, FUR, FURIN FROM PACE, furin (paired basic amino acid cleaving enzyme), furin, paired basic amino acid cleaving enzyme, PACE, PCSK3, SPC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Furin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YKGL motif
- peptide binding
- type VII secretion-associated serine protease mycosin
- Peptidase S8 pro-domain
- peptidase
- furin
- protease activator
- FU
- LI motif
- cytoplasmic domain
- VY motif
- growth factor binding
- FI motif
- casein kinase ii site internalization signal
- protease binding
- serine protease inhibitor activity
- Subtilase family
- enzyme regulator activity
- protein binding
- acidic domain
- glycosaminoglycan binding
- Peptidase domain in the S8 and S53 families
- endopeptidase
- binding protein
- serine endopeptidase
- serine-type peptidase
- Proprotein convertase P-domain
- transmembrane domain
- Furin-like repeats
- cytosolic tail domain
- pro domain
- heparin binding
Pathways
Biological processes and signaling networks where the Furin gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- schizophrenia
- bipolar disorder
- Danish type familial amyloid cardiomyopathy
- preeclampsia
- opioid-related disorder
- liver cancer
- coronary artery disease
- cannabis dependence
role in cell
- lysis
- expression in
- apoptosis
- proliferation
- formation
- activation in
- cell death
- production in
- migration
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-endosome fractions
- Golgi lumen
- perinuclear Golgi regions
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- intracellular storage compartment
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- basolateral cell surfaces
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- Golgi membrane
- trans Golgi network
- early endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- multivesicular bodies
- Golgi cisternae
- membrane rafts
- clathrin-coated vesicles
- immature secretory granules
- dense core granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Furin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cholesterol transport
- transforming growth factor beta receptor signaling pathway
- regulation of protein catabolic process
- signal peptide processing
- positive regulation of viral entry into host cell
- viral protein biosynthetic process
- nerve growth factor production
- zymogen activation
- viral protein processing
- negative regulation of low-density lipoprotein particle receptor catabolic process
- positive regulation of membrane protein ectodomain proteolysis
- negative regulation of nerve growth factor production
- plasma lipoprotein particle remodeling
- blastocyst formation
- protein maturation
- secretion by cell
- extracellular matrix disassembly
- regulation of signal transduction
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of transforming growth factor beta1 production
- peptide biosynthetic process
- extracellular matrix organization
- viral infectious cycle
- collagen catabolic process
- protein processing
- peptide hormone processing
- regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network transport vesicle
- Golgi membrane
- endoplasmic reticulum
- extracellular region
- Golgi lumen
- plasma membrane
- cell surface
- extracellular space
- trans-Golgi network
- extracellular vesicular exosome
- membrane
- membrane raft
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- metal ion binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- endopeptidase activity
- protease binding
- heparin binding
- peptide binding
- peptidase activity
- nerve growth factor binding