Trrap Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within regulation of DNA-templated transcription. Part of SAGA complex and transcription regulator complex. Is expressed in several structures, including cerebral cortex; cranial ganglion; submandibular gland primordium; tooth; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Trrap |
| Official Name | transformation/transcription domain-associated protein [Source:MGI Symbol;Acc:MGI:2153272] |
| Ensembl ID | ENSMUSG00000045482 |
| Bio databases IDs | |
| Aliases | transformation/transcription domain-associated protein |
| Synonyms | AI481500, DEDDFA, DFNA75, PAF350/400, PAF400, PCAF-associated factor 400, PAF400, STAF40, Tra1, transformation/transcription domain-associated protein, TR-AP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trrap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein kinase
- transcription co-activator
- Tra1 HEAT repeat ring region
- Phosphatidylinositol 3- and 4-kinase
- ATM-like domain
- transcription cofactor
- chromatin binding
- protein binding
- FATC domain
- FAT domain
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Tra1 HEAT repeat central region
Pathways
Biological processes and signaling networks where the Trrap gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- schizophrenia
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
- developmental delay with or without dysmorphic facies and autism
- developmental delay with dysmorphic facies without autism
- neurodevelopmental disorder
role in cell
- expression in
- proliferation
- apoptosis
- growth
- survival
- cell cycle progression
- transformation
- mitosis
- disruption
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Golgi Apparatus
- nucleosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trrap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- regulation of double-strand break repair
- regulation of DNA repair
- regulation of RNA splicing
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- transcription factor TFTC complex
- Swr1 complex
- Golgi apparatus
- nucleosome
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- kinase activity