App Gene Summary [Mouse]
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of primary metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | App |
| Official Name | amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059] |
| Ensembl ID | ENSMUSG00000022892 |
| Bio databases IDs | |
| Aliases | amyloid beta (A4) precursor protein |
| Synonyms | AAA, Abetapp, ABPP, AD1, Adap, Ag, alpha-sAPP, amyloid beta precursor protein, amyloid-beta-protein, Amyloidogenic glycoprotein, Amyloid precursor, amyloid β (A4) precursor, Amyloid β A4 precursor, amyloid β A4 precursor protein, amyloid β precursor, amyloid β precursor protein, amyloid-β-protein, amyloid β-protein precursor, APPI, appican, APP isoform 1, beta amyloid precursor, betaApp, CTFgamma, CVAP, E030013M08RIK, P3, PN2, PN-II, PreA4, protease nexin2, α-sAPP, β-amyloid precursor, β APP, β PP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse App often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylcholine receptor agonist
- growth factor receptor binding
- amyloid A4
- carbohydrate recognition domain
- protease activator
- identical protein binding
- amyloid beta precursor protein intracellular domain
- kinesin1 binding domain
- Beta-amyloid peptide (beta-APP)
- KPI domain
- GYENPTY motif
- NPXY motif
- cytoplasmic domain
- YENPTY motif
- chaperone binding
- cysteine rich domain
- gamma secretase cleavage site
- extracellular domain
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- protein kinase binding
- apoE binding site
- nucleic acid binding
- serine protease inhibitor activity
- ectodomain
- beta-secretase cleavage site
- Beta-amyloid precursor protein C-terminus
- E2 domain of amyloid precursor protein
- protein binding
- low-density lipoprotein receptor binding
- sequence-specific DNA binding
- glycosaminoglycan binding
- endocytic signal motif
- integrin binding
- transmembrane domain
- protein homodimerization
- receptor agonist activity
- Kunitz-type domain
- cytosolic tail domain
- protein heterodimerization
- JMTM_Notch_APP
- YxN Motif
- insulin receptor binding
- frizzled binding
- chemoattractant
- receptor activator
- caspase cleavage site
- G-protein-coupled receptor binding
- alpha-secretase cleavage site
- signal peptide
- ephrin receptor binding
- chromatin binding
- zinc binding domain
- Amyloid A4 N-terminal heparin-binding
- polypeptide hormone binding
- Kunitz-type protease inhibitor domain
- Copper-binding of amyloid precursor, CuBD
- growth factor domain
- copper binding domain
- basolateral sorting signal
- intracellular domain
- membrane-proximal domain
- PXY motif
- amyloid intracellular domain
- enzyme binding
- protein domain specific binding
- central domain
- receptor binding
- phosphotyrosine binding domain
- ASID
- antigenic epitope
- DNA binding
- phosphorylation site
- Fe65 binding domain
- binding protein
- double-stranded DNA binding
- Kunitz protease inhibitor domain
- E2 domain
- amyloid beta domain
Pathways
Biological processes and signaling networks where the App gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- obesity
- weight gain
- hypercholesterolemia
- hepatic steatosis
- epithelial cancer
- dementia
- pathogenesis
- neurodegeneration
- Alzheimer disease
role in cell
- apoptosis
- growth
- proliferation
- ubiquitination in
- formation
- formation in
- migration
- expression in
- phosphorylation in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- plasma membrane fraction
- early endosomal fractions
- synaptic plasma membrane fractions
- raft fractions
- soluble fraction
- endoplasmic reticulum fraction
- golgi/trans-golgi network-rich vesicle fraction
- Golgi-enriched fraction
- low-density microsomal fraction
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- synaptosomal membrane fractions
- Golgi lumen
- lipofuscin-like dots
- thorny excrescence
- intracellular membrane-bounded organelle
- intracellular compartment
- exocytic vesicle
- Cytoplasm
- presynaptic regions
- cell surface
- perinuclear membrane
- Extracellular Space
- cell periphery
- intracellular space
- intranuclear region
- apical compartment
- somatodendritic region
- perinuclear region
- postsynaptic region
- peripheral lamellae
- cellular membrane
- filamentous network
- Nucleus
- endosomes
- sarcoplasmic reticulum
- annulate lamellae
- vesicles
- centrosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- actin filaments
- intercellular junctions
- granules
- cytosol
- endoplasmic reticulum lumen
- caveolar membranes
- ciliary rootlet
- granular components
- trans Golgi network
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrial inner membrane
- endosomal compartment
- endosomal membrane
- perinuclear space
- nuclear envelope
- alpha granules
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- myofibrils
- recycling endosomes
- early endosomes
- late endosomes
- transport vesicles
- cytoplasmic vesicles
- secretory vesicles
- multivesicular bodies
- secretory granules
- extracellular matrix
- Golgi cisternae
- membrane rafts
- detergent insoluble microdomains
- filopodia
- central spindle
- postsynaptic spines
- perikaryon
- axons
- dendrites
- postsynaptic density
- presynaptic terminals
- dendritic shafts
- axonal shafts
- astrocyte projections
- Golgi vesicles
- chromaffin vesicles
- clathrin-coated vesicles
- plasma
- glial limiting membrane
- cis Golgi cisternae
- lamellipodia
- apical processes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse App gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of epidermal growth factor-activated receptor activity
- visual learning
- adult locomotory behavior
- learning
- learning or memory
- positive regulation of protein metabolic process
- smooth endoplasmic reticulum calcium ion homeostasis
- cellular copper ion homeostasis
- synaptic growth at neuromuscular junction
- forebrain development
- regulation of long-term neuronal synaptic plasticity
- axonogenesis
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- ionotropic glutamate receptor signaling pathway
- neuron apoptotic process
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of G2/M transition of mitotic cell cycle
- synapse organization
- positive regulation of inflammatory response
- endocytosis
- positive regulation of mitotic cell cycle
- mating behavior
- positive regulation of T cell migration
- negative regulation of gene expression
- central nervous system development
- Notch signaling pathway
- positive regulation of gene expression
- regulation of gene expression
- regulation of synapse structure and activity
- response to interleukin-1
- neuron remodeling
- positive regulation of interleukin-6 production
- neuromuscular process controlling balance
- negative regulation of long-term synaptic potentiation
- regulation of multicellular organism growth
- positive regulation of long-term synaptic potentiation
- axon cargo transport
- negative regulation of cell proliferation
- negative regulation of neuron differentiation
- cholesterol metabolic process
- cell adhesion
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- astrocyte activation involved in immune response
- positive regulation of glycolysis
- regulation of translation
- positive regulation of calcium-mediated signaling
- regulation of peptidyl-tyrosine phosphorylation
- response to oxidative stress
- astrocyte activation
- locomotory behavior
- G2/M transition of mitotic cell cycle
- cognition
- suckling behavior
- axon midline choice point recognition
- dendrite development
- neuron projection development
- collateral sprouting in absence of injury
- microglial cell activation
- neuron homeostasis
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- extracellular matrix organization
- positive regulation of peptidyl-threonine phosphorylation
- regulation of Wnt receptor signaling pathway
- positive regulation of interleukin-1 beta production
- microglia development
Cellular Component
Where in the cell the gene product is active
- smooth endoplasmic reticulum
- synaptic vesicle
- Golgi apparatus
- synapse
- extracellular region
- perikaryon
- Golgi lumen
- Golgi-associated vesicle
- growth cone
- endoplasmic reticulum lumen
- dendrite
- early endosome
- endosome
- extracellular vesicular exosome
- presynaptic active zone
- apical part of cell
- dendritic shaft
- coated pit
- dendritic spine
- cytosol
- neuromuscular junction
- axon
- trans-Golgi network membrane
- ciliary rootlet
- platelet alpha granule lumen
- endoplasmic reticulum
- receptor complex
- nuclear envelope lumen
- plasma membrane
- mitochondrial inner membrane
- cell surface
- extracellular space
- spindle midzone
- cell-cell junction
- perinuclear region of cytoplasm
- cytoplasm
- membrane raft
- endosome lumen
- membrane
- ER to Golgi transport vesicle
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transition metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- receptor agonist activity
- heparin binding
- receptor binding
- receptor activator activity
- DNA binding
- serine-type endopeptidase inhibitor activity
- protein binding
- enzyme binding
- PTB domain binding