Fbn2 Gene Summary [Rat]
Predicted to enable hormone activity. Predicted to be involved in several processes, including bone trabecula formation; eye development; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within embryonic limb morphogenesis. Predicted to be located in extracellular region and microfibril. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital contractural arachnodactyly and scoliosis. Orthologous to human FBN2 (fibrillin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbn2 |
| Official Name | fibrillin 2 [Source:RGD Symbol;Acc:620910] |
| Ensembl ID | ENSRNOG00000043219 |
| Bio databases IDs | |
| Aliases | fibrillin 2 |
| Synonyms | BC063774, CCA, DA9, EOMD, Fib-2, fibrillin 2, LOC102553271, mKIAA4226, RGD1563221, sne, sy |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- calcium ion binding
- TB domain
- hormone
- EGF domain
- protein binding
- hybrid domain
- Fibrillin 1 unique N-terminal domain
- EGF-like domain
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- cancer
- congenital contractural arachnodactyly
- hypertension
- pancreatic cancer
- familial thoracic aortic aneurysms and dissections
- refractive error
- polysyndactyly
- obesity
- cardiovascular disorder
regulates
- D-glucose
- cyclic AMP
- PKA
- MMP9
- G6PC1
- PEPCK
role in cell
- growth
- differentiation
- invasion by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microfibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sequestering of TGFbeta in extracellular matrix
- embryonic limb morphogenesis
- signal transduction
- embryonic eye morphogenesis
- camera-type eye development
- anatomical structure morphogenesis
- positive regulation of osteoblast differentiation
- bone trabecula formation
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- microfibril
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- extracellular matrix constituent conferring elasticity
- hormone activity
- extracellular matrix structural constituent