Matn2 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to act upstream of or within neurogenesis and response to axon injury. Predicted to be located in basement membrane. Predicted to be part of matrilin complex. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human MATN2 (matrilin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Matn2 |
| Official Name | matrilin 2 [Source:RGD Symbol;Acc:1305353] |
| Ensembl ID | ENSRNOG00000006060 |
| Bio databases IDs | |
| Aliases | matrilin 2 |
| Synonyms | Crtm2, LOC100503446, matrilin-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Matn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- Trimeric coiled-coil oligomerization domain of matrilin
- vWFA
- extracellular matrix structural constituent
- coiled-coil domain
- EGF domain
- protein binding
- von Willebrand factor type A domain
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- oral squamous cell carcinoma
- eosinophilic esophagitis
- squamous cell cancer of the oral cavity
- plexiform neurofibroma
- impotence
- uterine serous papillary cancer
- autosomal dominant polycystic kidney disease
role in cell
- migration
- number
- morphogenesis
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell-associated matrix
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Matn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- extracellular matrix organization
- axon guidance
- response to axon injury
- dendrite regeneration
- glial cell migration
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- extracellular matrix structural constituent