Tat Gene Summary [Rat]
Enables L-tyrosine-2-oxoglutarate transaminase activity and amino acid binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to glucocorticoid. Located in cytosol. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tat |
| Official Name | tyrosine aminotransferase [Source:RGD Symbol;Acc:3820] |
| Ensembl ID | ENSRNOG00000016348 |
| Bio databases IDs | |
| Aliases | tyrosine aminotransferase |
| Synonyms | MGC37790, tyrosine aminotransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- acetylation site
- tyrosine aminotransferase, eukaryotic
- tyrosine transaminase
- AAT_I
- Aminotransferase ubiquitination site
- enzyme
- protein binding
- Aminotransferase class I and II
- identical protein binding
- amino acid binding
Pathways
Biological processes and signaling networks where the Tat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- tyrosinemia type II
- sepsis
role in cell
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- glutamate metabolic process
- L-phenylalanine catabolic process
- response to mercury ion
- tyrosine catabolic process
- biosynthetic process
- 2-oxoglutarate metabolic process
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- identical protein binding
- protein binding
- L-tyrosine:2-oxoglutarate aminotransferase activity
- amino acid binding