Eln Gene Summary [Rat]
Enables extracellular matrix constituent conferring elasticity. Involved in several processes, including cellular response to L-ascorbic acid; cellular response to dexamethasone stimulus; and cellular response to retinoic acid. Located in extracellular space. Used to study abdominal aortic aneurysm. Biomarker of autosomal recessive polycystic kidney disease; bladder neck obstruction; congenital diaphragmatic hernia; liver cirrhosis; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eln |
| Official Name | elastin [Source:RGD Symbol;Acc:67394] |
| Ensembl ID | ENSRNOG00000001469 |
| Bio databases IDs | |
| Aliases | elastin |
| Synonyms | ADCL1, E030024M20RIK, ELASTIN, RATTREL11, SVAS, TE, TREL11, Trela, Trela26, Tropoelastin, WBS, WS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix constituent conferring elasticity
- extracellular matrix binding
- hydrophilic domain
- extracellular matrix structural constituent
- central domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- supravalvular aortic stenosis
- hereditary disorder
- autosomal dominant cutis laxa type 1
- amyotrophic lateral sclerosis
- stenosis
- Williams-Beuren syndrome
- diverticular disease
- hypertension
- cardiac hypertrophy
- laser induced choroidal neovascularization
role in cell
- migration
- proliferation
- formation
- adhesion
- transmigration
- organization
- chemotaxis
- orientation
- polymerization
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Endoplasmic Reticulum
- peripheral vesicles
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- regulation of smooth muscle cell proliferation
- aortic valve morphogenesis
- skeletal muscle tissue development
- outflow tract morphogenesis
- blood circulation
- extracellular matrix assembly
- respiratory gaseous exchange
- stress fiber assembly
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- elastic fiber
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- extracellular matrix constituent conferring elasticity
- extracellular matrix structural constituent