Sec14l2 Gene Summary [Rat]
Enables enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec14l2 |
| Official Name | SEC14-like lipid binding 2 [Source:RGD Symbol;Acc:621779] |
| Ensembl ID | ENSRNOG00000004672 |
| Bio databases IDs | |
| Aliases | SEC14-like lipid binding 2 |
| Synonyms | 1300013M05Rik, C22orf6, SEC14-like lipid binding 2, SPF, TAP, TAP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec14l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- CRAL/TRIO, N-terminal domain
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- enzyme activator activity
- Non-methyl alkyl or aryl group transferase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
regulates
- AKT
- cholesterol
- PIK3 p110
- PI3K p85
- VLDL/cholesterol
- squalene
- vitamin E
role in cell
- growth
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec14l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cholesterol biosynthetic process
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- vitamin E binding
- phospholipid binding