Apex1 Gene Summary [Rat]
Enables NF-kappaB binding activity and RNA endonuclease activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of G1/S transition of mitotic cell cycle. Part of transcription regulator complex. Biomarker of brain ischemia; hepatocellular carcinoma; lung disease; and status epilepticus. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apex1 |
| Official Name | apurinic/apyrimidinic endodeoxyribonuclease 1 [Source:RGD Symbol;Acc:2126] |
| Ensembl ID | ENSRNOG00000009663 |
| Bio databases IDs | |
| Aliases | apurinic/apyrimidinic endodeoxyribonuclease 1 |
| Synonyms | APE, APE1, APEN, APEX, APEX NUCLEASE, apurinic/apyrimidinic endodeoxyribonuclease 1, apurinic/apyrimidinic endonuclease 1, APX, HAP1, REF-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apex1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphodiesterase I
- 3'-5' exonuclease
- transcription co-activator
- transcription co-repressor
- chromatin binding
- enzyme
- double-stranded DNA specific exodeoxyribonuclease
- 3'-5' exodeoxyribonuclease
- endonuclease
- ribonuclease H
- uracil DNA N-glycosylase
- phosphoric diester hydrolase
- oxidoreductase
- NF-kappaB binding
- 5' phosphomonoester producing endodeoxyribonuclease
- metal ion binding
- Endonuclease/Exonuclease/phosphatase family
- DNA-(apurinic or apyrimidinic site) lyase
- protein binding
- DNA binding
- binding protein
- altered base-specific endodeoxyribonuclease
- double-stranded telomeric DNA binding
- damaged DNA binding
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- endoribonuclease
Pathways
Biological processes and signaling networks where the Apex1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- cancer
- endometriosis
- growth failure
- brain cancer
- central nervous system cancer
- head and neck cancer
- head and neck neoplasia
- lung adenocarcinoma
role in cell
- expression in
- phosphorylation in
- cell death
- apoptosis
- migration
- proliferation
- invasion by
- activation in
- accumulation in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- perinuclear body
- Cytoplasm
- perinuclear region
- membrane surface
- ribosome
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- granules
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear speckles
- Nissl substance
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apex1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- DNA recombination
- telomere maintenance
- cell redox homeostasis
- regulation of mRNA stability
- regulation of apoptotic process
- base-excision repair, gap-filling
- positive regulation of transcription from RNA polymerase II promoter
- hypomethylation of CpG island
- DNA catabolic process
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- nuclear speck
- mitochondrion
- endoplasmic reticulum
- nucleolus
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- 3'-5'-exodeoxyribonuclease activity
- double-stranded telomeric DNA binding
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- endodeoxyribonuclease activity
- damaged DNA binding
- apurinic/apyrimidinic endodeoxyribonuclease activity
- double-stranded DNA specific exodeoxyribonuclease activity
- 3'-5' exonuclease activity
- ribonuclease H activity
- DNA binding
- protein binding
- RNA binding
- uracil DNA N-glycosylase activity
- phosphodiesterase I activity
- transcription coactivator activity
- oxidoreductase activity
- metal ion binding
- transcription corepressor activity
- endonuclease activity
- site-specific endodeoxyribonuclease activity, specific for altered base
- DNA-(apurinic or apyrimidinic site) lyase activity
- phosphoric diester hydrolase activity