Ifitm5 Gene Summary [Mouse]
Involved in bone mineralization; bone morphogenesis; and in utero embryonic development. Acts upstream of or within response to rapamycin; response to tacrolimus; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including bone; genitourinary system; limb cartilage condensation; perichondrium; and spleen. Used to study osteogenesis imperfecta type 5. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 5. Orthologous to human IFITM5 (interferon induced transmembrane protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifitm5 |
| Official Name | interferon induced transmembrane protein 5 [Source:MGI Symbol;Acc:MGI:1934923] |
| Ensembl ID | ENSMUSG00000025489 |
| Bio databases IDs | |
| Aliases | interferon induced transmembrane protein 5 |
| Synonyms | 1110003J06Rik, BRIL, DSPA1, fragilis4, Hrmp1, Hrtm1, interferon induced transmembrane protein 5, OI5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifitm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced transmembrane protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- infection
- osteosarcoma
- osteosarcomagenesis
- osteogenesis imperfecta type V
- osteogenesis imperfecta
phenotypes
- abnormal bone marrow cavity morphology
- abnormal bone ossification
- abnormal clavicle morphology
- abnormal compact bone morphology
- abnormal cranium morphology
- abnormal ilium body morphology
- abnormal intramembranous bone ossification
- abnormal limb morphology
- abnormal long bone diaphysis morphology
- abnormal mandible morphology
- abnormal neurocranium morphology
- abnormal osteoblast physiology
- abnormal osteoclast morphology
- abnormal premaxilla morphology
- abnormal rib morphology
- abnormal skeleton morphology
- abnormal thoracic cage morphology
- abnormal trabecular bone morphology
- absent compact bone
- bowed radius
- bowed tibia
- bowed ulna
- clavicle hypoplasia
- decreased alkaline phosphatase activity
- decreased body weight
- decreased bone mineralization
- decreased bone trabecula number
- decreased bone volume
- decreased compact bone area
- decreased compact bone thickness
- decreased length of long bones
- decreased litter size
- decreased trabecular bone volume
- disorganized long bone epiphyseal plate
- impaired osteoblast differentiation
- increased bone trabecular spacing
- increased osteoid volume
- increased width of hypertrophic chondrocyte zone
- mandible hypoplasia
- neonatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
- short femur
- short limbs
- short mandible
- small clavicle
- thin frontal bone
role in cell
- development
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifitm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- in utero embryonic development
- bone morphogenesis
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane