Ikbip Gene Summary [Mouse]
Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; response to interleukin-1; and response to tumor necrosis factor. Predicted to be located in endoplasmic reticulum and nucleolus. Is expressed in mandible; maxilla; and rib. Orthologous to human IKBIP (IKBKB interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikbip |
| Official Name | IKBKB interacting protein [Source:MGI Symbol;Acc:MGI:1914704] |
| Ensembl ID | ENSMUSG00000019975 |
| Bio databases IDs | |
| Aliases | IKBKB interacting protein |
| Synonyms | 1200009F10Rik, 1700023M03Rik, FLJ31051, IKBKB interacting protein, IKIP, RGD1305457 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ikbip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Barrett syndrome
- lung injury
- mantle cell lymphoma
- dextran sodium sulfate-induced colitis
role in cell
- phosphorylation in
- expression in
- activation in
- binding in
- cellular infiltration by
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ikbip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to X-ray
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding