Pgam5 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process and negative regulation of cold-induced thermogenesis. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgam5 |
| Official Name | phosphoglycerate mutase family member 5 [Source:MGI Symbol;Acc:MGI:1919792] |
| Ensembl ID | ENSMUSG00000029500 |
| Bio databases IDs | |
| Aliases | phosphoglycerate mutase family member 5 |
| Synonyms | 2610528A17Rik, BXLBV68, MGC5352, PGAM family member 5, mitochondrial serine/threonine protein phosphatase, phosphoglycerate mutase family member 5, RGD1312028 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgam5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Histidine phosphatase superfamily (branch 1)
- protein serine/threonine phosphatase
- protein phosphatase
- Phosphoglycerate mutase family
- phosphatase
- GTPase activator
- enzyme
- protein binding
- Histidine phosphatase domain
- ESGE motif
Pathways
Biological processes and signaling networks where the Pgam5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
phenotypes
- decreased circulating glucose level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased exploration in new environment
- decreased total retina thickness
- hypoactivity
- increased body length
- short tibia
- abnormal gait
- abnormal interleukin-1 beta secretion
- abnormal locomotor activation
- abnormal macrophage activation involved in immune response
- abnormal mitochondrial crista morphology
- abnormal mitochondrial physiology
- abnormal mitochondrial shape
- abnormal mitochondrion morphology
- abnormal motor coordination/ balance
- abnormal redox activity
- akinesia
- bradykinesia
- decreased body size
- decreased body weight
- decreased dopamine level
- decreased interleukin-1 beta secretion
- decreased survivor rate
- decreased vertical activity
- loss of dopaminergic neurons
- neuron degeneration
- oxidative stress
- premature death
- prenatal lethality incomplete penetrance
- short stride length
role in cell
- expression in
- growth
- phosphorylation in
- production in
- cell death
- formation
- formation in
- degeneration
- cellular infiltration by
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgam5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- necroptosis
- positive regulation of mitochondrial fission
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- GTPase activator activity
- phosphatase activity
- myosin phosphatase activity