Eri1 Gene Summary [Mouse]
Enables histone pre-mRNA stem-loop binding activity; rRNA binding activity; and ribosome binding activity. Involved in rRNA 3'-end processing. Located in cytoplasm and nucleolus. Part of histone pre-mRNA 3'end processing complex. Is expressed in early conceptus; eye; inner cell mass; limb; and oocyte. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eri1 |
| Official Name | exoribonuclease 1 [Source:MGI Symbol;Acc:MGI:1914526] |
| Ensembl ID | ENSMUSG00000031527 |
| Bio databases IDs | |
| Aliases | exoribonuclease 1 |
| Synonyms | 3110010F15Rik, 3'HEXO, exoribonuclease 1, HEXO, HXAL, RGD1308378, SEMDGC, SEMDGS, THEX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eri1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exonuclease
- SAP motif
- rRNA binding
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- SAP domain
- EXOIII
- ribosome binding
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- Guo-Campeau type spondyloepimetaphyseal dysplasia
- neuroticism
- Crohn disease
- Hoxha-Aliu syndrome
- myopia
- atrial fibrillation
- pathologic myopia
regulates
- histone H2A
- SLBP
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eri1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- histone mRNA catabolic process
- gene silencing by RNA
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- rRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- histone pre-mRNA 3'end processing complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- 3'-5'-exoribonuclease activity
- protein binding
- metal ion binding
- ribosome binding
- rRNA binding
- histone pre-mRNA stem-loop binding