Btf3 Gene Summary [Mouse]
Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btf3 |
| Official Name | basic transcription factor 3 [Source:MGI Symbol;Acc:MGI:1202875] |
| Ensembl ID | ENSMUSG00000021660 |
| Bio databases IDs | |
| Aliases | basic transcription factor 3 |
| Synonyms | 1700054E11RIK, basic transcription factor 3, BETA-NAC, NACB, β-NAC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- NAC domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- pancreatic epithelial cancer
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
role in cell
- apoptosis
- phosphorylation in
- pyroptosis
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- protein transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- nascent polypeptide-associated complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding