Lsm1 Gene Summary [Mouse]
Predicted to enable mRNA binding activity and pre-mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Located in P-body. Is expressed in central nervous system; heart; metanephros; and submandibular gland. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsm1 |
| Official Name | LSM1 homolog, mRNA degradation associated [Source:MGI Symbol;Acc:MGI:1914457] |
| Ensembl ID | ENSMUSG00000037296 |
| Bio databases IDs | |
| Aliases | LSM1 homolog, mRNA degradation associated |
| Synonyms | 2810025O06Rik, CASM, LSM1 homolog, mRNA degradation associated, Sm, YJL124C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lsm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- mRNA binding
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Lsm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- breast cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- lupus nephritis
- schizophrenia
- neoplastic cell transformation
- global developmental delay
role in cell
- growth
- differentiation
- formation
- accumulation in
- cell cycle progression
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cytoplasmic mRNA processing body
- Cytoplasm
- cytosol
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lsm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- stem cell maintenance
- neuron differentiation
- histone mRNA catabolic process
- negative regulation of neuron differentiation
- deadenylation-dependent decapping of nuclear-transcribed mRNA
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- protein binding
- mRNA binding