Thsd7b Gene Summary [Mouse]

Predicted to be involved in actin cytoskeleton organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryo. Orthologous to human THSD7B (thrombospondin type 1 domain containing 7B). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Retained Intron
Official Symbol
Thsd7b
Official Name
thrombospondin, type I, domain containing 7B [Source:MGI Symbol;Acc:MGI:2443925]
Ensembl ID
ENSMUSG00000042581
Bio databases IDs NCBI: 210417 Ensembl: ENSMUSG00000042581
Aliases thrombospondin, type I, domain containing 7B
Synonyms 1700074E13Rik, B930082A18, D130067I03Rik, RGD1306938, thrombospondin type 1 domain containing 7B, thrombospondin, type I, domain containing 7B
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thsd7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Thrombospondin type 1 repeats
  • Thrombospondin type 1 domain
  • protein binding
  • Spondin-like TSP1 domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • non-small cell lung cancer
  • COVID-19
  • obesity
  • schizophrenia
  • acute myeloid leukemia
  • colon carcinoma
  • colon epithelial cancer
  • insomnia
  • metabolic syndrome X
regulated by
  • beta-estradiol
  • tetrodotoxin
  • GRIN3A

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Thsd7b gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • actin cytoskeleton organization

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.