Grin3a Gene Summary [Mouse]
Enables NMDA glutamate receptor activity; calcium channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within calcium ion transport; dendrite development; and prepulse inhibition. Located in neuronal cell body and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; foot bone; and hand mesenchyme. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin3a |
| Official Name | glutamate receptor ionotropic, NMDA3A [Source:MGI Symbol;Acc:MGI:1933206] |
| Ensembl ID | ENSMUSG00000039579 |
| Bio databases IDs | |
| Aliases | glutamate receptor ionotropic, NMDA3A |
| Synonyms | 6430537F04, A830097C19, A830097C19Rik, chi-1, GluN3A, glutamate ionotropic receptor NMDA type subunit 3A, glutamate receptor ionotropic, NMDA3A, mKIAA1973, Nmda3a, NMDAR3A, NMDAR-L, NR3, NR3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grin3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- calcium channel
- protein phosphatase binding
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- extracellular ligand-gated ion channel
- protein binding
- identical protein binding
- ion channel
- amino acid binding
- N-methyl-D-aspartate selective glutamate receptor
- neurotransmitter receptor
- binding protein
- glycine binding
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
- intracellular domain
- cation channel
Pathways
Biological processes and signaling networks where the Grin3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- cancer
- chronic pain
- metastatic non-small cell lung cancer
- bronchospasm
- chronic obstructive pulmonary disease
- asthma
- hyperalgesia
- nausea
- pain
role in cell
- proliferation
- expression in
- phosphorylation in
- firing
- cell viability
- cell death
- abnormal morphology
- density
- plasticity
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- Cytoplasm
- synaptic cleft
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- postsynaptic membrane
- synaptic membrane
- synaptic components
- neurites
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grin3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- regulation of postsynaptic membrane potential
- prepulse inhibition
- rhythmic process
- negative regulation of dendritic spine development
- calcium ion transport
- calcium ion transmembrane transport
- regulation of synaptic transmission
- ionotropic glutamate receptor signaling pathway
- dendrite development
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- synapse
- neuronal cell body
- N-methyl-D-aspartate selective glutamate receptor complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glutamate receptor activity
- calcium channel activity
- glycine binding
- protein phosphatase 2A binding
- N-methyl-D-aspartate selective glutamate receptor activity