Kcnj6 Gene Summary [Mouse]
Enables inward rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Contributes to G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in membrane. Part of inward rectifier potassium channel complex. Is active in parallel fiber to Purkinje cell synapse; postsynapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj6 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 6 [Source:MGI Symbol;Acc:MGI:104781] |
| Ensembl ID | ENSMUSG00000043301 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 6 |
| Synonyms | BIR1, GIRK-2, hiGIRK2, KATP-2, KCNJ7, KIR3.2, KPLBS, potassium inwardly rectifying channel subfamily J member 6, potassium inwardly-rectifying channel, subfamily J, member 6, weaver, wv |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- phosphatidylinositol 4,5-biphosphate binding domain
- inward rectifier potassium channel
- G-protein activated inward rectifier potassium channel
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- pore domain
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Kcnj6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- breast cancer
- Down syndrome
- neurodegeneration
- dementia
- pain
- Parkinson disease
- environmentally induced seizure
- Keppen-Lubinsky syndrome
- nystagmus
role in cell
- apoptosis
- survival
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- presynaptic regions
- cell surface
- somatodendritic region
- perinuclear region
- postsynaptic region
- cellular membrane
- lysosome
- presynaptic membrane
- postsynaptic membrane
- neurites
- nerve ending
- late endosomes
- perikaryon
- axons
- dendrites
- excitatory synapses
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein activated inward rectifier potassium channel activity
- protein binding
- inward rectifier potassium channel activity