Gpr37l1 Gene Summary [Mouse]
Predicted to enable G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in cellular response to reactive oxygen species; negative regulation of systemic arterial blood pressure; and positive regulation of MAPK cascade. Acts upstream of or within negative regulation of cell differentiation; negative regulation of smoothened signaling pathway; and positive regulation of cerebellar granule cell precursor proliferation. Located in plasma membrane. Is expressed in brain; dentate gyrus subgranular zone; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human GPR37L1 (G protein-coupled receptor 37 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr37l1 |
| Official Name | G protein-coupled receptor 37-like 1 [Source:MGI Symbol;Acc:MGI:1928503] |
| Ensembl ID | ENSMUSG00000026424 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 37-like 1 |
| Synonyms | CAG-18, D0Kist8, ET(B)R-LP-2, ETBR-LP-2, Gpcr 37-like 1, G protein-coupled receptor 37-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr37l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- peptide binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr37l1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- hydrocephalus
- hypersensitive reaction
- astrocytosis
- central nervous system cancer
- head and neck cancer
- brain cancer
- head and neck neoplasia
- diverticular disease
role in cell
- differentiation
- proliferation
- phosphorylation in
- maturation
- abnormal morphology
- response by
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr37l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- Bergmann glial cell differentiation
- negative regulation of systemic arterial blood pressure
- negative regulation of neuron differentiation
- positive regulation of cerebellar granule cell precursor proliferation
- negative regulation of astrocyte differentiation
- smoothened signaling pathway
- positive regulation of MAPK cascade
- negative regulation of smoothened signaling pathway
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- peptide binding