SLC4A8 Gene Summary [Human]
The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | SLC4A8 |
| Official Name | solute carrier family 4 member 8 [Source:HGNC Symbol;Acc:HGNC:11034] |
| Ensembl ID | ENSG00000050438 |
| Bio databases IDs | |
| Aliases | solute carrier family 4 member 8 |
| Synonyms | AW493845, C230026C11, Hco3-/cl- exchanger, kNBC-3, LOC283400, NBC3, NDCBE, NDCBE1, solute carrier family 4 (anion exchanger), member 8, solute carrier family 4 member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC4A8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium ion transporter
- anion exchange protein
- metal ion transporter
- identical protein binding
- chloride transporter
- bicarbonate transporter
- anion transporter
- sodium:bicarbonate symporter
- HCO3- transporter family
- Band 3 cytoplasmic domain
- zinc ion binding
- antiporter
- inorganic anion exchanger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- primary dendrite
- presynaptic regions
- perinuclear region
- cellular membrane
- vesicles
- presynaptic membrane
- basolateral membrane
- synaptic vesicles
- neurites
- synaptosomes
- synapse
- glial cell projections
- perikaryon
- axons
- dendrites
- axon terminals
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC4A8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intracellular pH
- transmembrane transport
- regulation of membrane potential
- regulation of synaptic transmission
- sodium ion transmembrane transport
- bicarbonate transport
- positive regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- symmetric synapse
- synaptic vesicle
- neuronal cell body membrane
- neuron projection
- axon terminus
- plasma membrane
- dendrite
- terminal button
- membrane
- asymmetric synapse
- synaptic vesicle membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sodium:bicarbonate symporter activity
- inorganic anion exchanger activity
- sodium ion transmembrane transporter activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity