RAB21 Gene Summary [Human]
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | RAB21 |
| Official Name | RAB21, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:18263] |
| Ensembl ID | ENSG00000080371 |
| Bio databases IDs | |
| Aliases | RAB21, member RAS oncogene family |
| Synonyms | 9630024B22, KIAA0118, RAB21, member RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sickle cell anemia
role in cell
- phosphorylation in
- formation
- adhesion
- quantity
- extension
- migration
- morphogenesis
- exocytosis by
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- detergent resistant lipid raft fraction
- cell surface
- endosomes
- Golgi Apparatus
- cytosol
- cytoplasmic face of plasma membrane
- vesicle membrane
- trans Golgi network
- endosomal membrane
- neurites
- synapse
- early endosomes
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of axon extension
- anterograde axon cargo transport
- Rab protein signal transduction
- positive regulation of early endosome to late endosome transport
- regulation of exocytosis
- protein stabilization
- intracellular protein transport
- positive regulation of receptor-mediated endocytosis
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- Golgi cisterna membrane
- Golgi membrane
- synapse
- internal side of plasma membrane
- early endosome membrane
- endoplasmic reticulum membrane
- early endosome
- trans-Golgi network
- extracellular vesicular exosome
- endosome
- focal adhesion
- vesicle membrane
- endomembrane system
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding